DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and Sema6d

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_006499174.1	Gene:	Sema6d / 214968	MGIID:	2387661	Length:	1086	Species:	Mus musculus

Alignment Length:	808	Identity:	237/808 - (29%)
Similarity:	355/808 - (43%)	Gaps:	180/808 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLLVLVAQTVHVEYARADYE-NTWNLYY--EPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFY 126
            :|.:||::...|.:...|.. ||.:.:|  :.|...|..:.    :..:|..||.         .
Mouse    10 VLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSG----NESQHRLDFQ---------L 61

  Fly   127 MDERNNALYVGAMDRIFRLNLRNISQS-ICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVI 190
            |.:..:.||:...|:::.:||..|.|: :.....|.......|..||..||| .|.||.|.|:|.
Mouse    62 MLKIRDTLYIAGRDQVYTVNLNEIPQTEVIPSKKLTWRSRQQDRENCAMKGK-HKDECHNFIKVF 125

  Fly   191 QPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGN 255
            .|.  |.:.::||||||.||.     .....|...:|......|:.:||:|....:.|::.:.
Mouse   126 VPR--NDEMVFVCGTNAFNPM-----CRYYRLRTLEYDGEEISGLARCPFDARQTNVALFADG-- 181

  Fly   256 PFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFV 320
                 .||:.|.|:|..:|:||:||        ..:.:..||:|||||.:.:|:|:.:.|.|.:|
Mouse   182 -----KLYSATVADFLASDAVIYRS--------MGDGSALRTIKYDSKWIKEPHFLHAIEYGNYV 233

  Fly   321 YFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPFYFNEIQ 384
            ||||||.|||:.|.||||||||||:||||.|| :.::.::|.::||||:|||:..:..|||:.:|
Mouse   234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQ 298

  Fly   385 SVYK------MPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLN 443
            |:..      :||    ....|||..|.:.|||||::.:.||...|.|:||||.|.:|.|..|..
Mouse   299 SITDIIQINGIPT----VVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPE 359

  Fly   444 SKVPEPRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDV--ILTKL 498
            .|||:||||.|        :..:...||..|.||:.|||||.||......|.|.|..|  .||.:
Mouse   360 DKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424

  Fly   499 VVDKIRIDKLNQEFLVYFVATTSGHIYKIV-QFMHYGQRHSNLVDIFEA------SPHSEPIRE- 555
            .||  |.....|.:.|.||.:.:|.:.|:: :...:....|.|::..||      |..||..|:
Mouse   425 EVD--RSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKV 487

  Fly   556 --MTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGWDKDVNACRPYQLGLLQ 615
              :.|.....:||||....|.:|.::.| .||.||.: |::  ||||||
Mouse   488 VSLQLDKDHHALYVAFSSCVVRIPLSRC-ERYGSCKKSCIASRDPYCGW---------------- 535

  Fly   616 DVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKY 680
                .:.|:|:...|        |..|....|             :..|:...|.||.
Mouse   536 ----LSQGVCERVTL--------GMLLLTEDF-------------FAFHNHSPGGYEQ------- 568

  Fly   681 IDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKY 745
             ||..|....|.                         |.|...|||...|| ||:....::.|..
Mouse   569 -DTEYGNTAHLG-------------------------DCHESLPPSTTPDY-KIFGGPTSDMEVS 606

  Fly   746 KSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALVXPRKYLYS--------FEFLSSATE 802
            .|::....:..|          |:|.   |.|.: ...|. .||::..        .:.:|...:
Mouse   607 SSSVTTVASSPE----------ITSK---VIDTW-RPKLTSSRKFVVQDDPNTSDFTDTISGIPK 657

  Fly   803 GV------ASAHRKLYIFVFVLTIFARF 824
            ||      ..:::.:::.|.:..:||.|
Mouse   658 GVRWEVQSGESNQMVHMNVLITCVFAAF 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	172/486 (35%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	12/87 (14%)
Sema6d	XP_006499174.1	Sema	49..513	CDD:417757	175/505 (35%)
		PSI	514..>543	CDD:396154	14/49 (29%)
		PHA03247	<922..1069	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910