Protein Alignment Sema2b and Sema7a

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_035482.1
• Gene: Sema7a / 20361
• MGIID: 1306826
• Length: 664
• Species: Mus musculus
• Alignment Length: 681
• Identity: 164/681 - (24%)
• Similarity: 269/681 - (39%)
• Gaps: 167/681 - (24%)

  Fly   109 KEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNL---RNISQSICERDVLILEPTGSDIL 170
            ::|| ||| .|..:...:.:..:.:::||...:::..|.   :|.|    .|.|.|....||
Mouse    61 QDHV-DFS-QPEPHTVLFHEPGSFSVWVGGRGKVYHFNFPEGKNAS----VRTVNIGSTKGS--- 116

  Fly   171 NCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGI 235
             |     ::|.:|.|:|.:::.   .|..|.||||||..|..:       :|.....|..:|...
Mouse   117 -C-----QDKQDCGNYITLLER---RGNGLLVCGTNARKPSCW-------NLVNDSVVMSLGEMK 165

  Fly   236 GKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFK----R 296
            |..|:.|.:||.                            |:|..|....|..::|.|.|    |
Mouse   166 GYAPFSPDENSL----------------------------VLFEGDEVYSTIRKQEYNGKIPRFR 202

  Fly   297 TVKYDSKL------LDKPNFVGSFEI------GEFVYFFFREHAVEYINCGKAVYSRVARVCKND 349
            .::.:|:|      :..|.|:.:..:      .:.:|:||||...:.........||||::|:.|
Mouse   203 RIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGD 267

  Fly   350 RGGKYMIS-QNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTD-----DTKFYATFTTNTNGLI 408
            :||:..:| ..|.|:|||.:.|| .:.....||.:|.|:.:|..     ||:.|..|:...|
Mouse   268 QGGESSLSVSKWNTFLKAMLVCS-DAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWN--- 328

  Fly   409 GSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHP 473
            .||||.|.:.||:..|       .||:   |...:..:|.||||.|......:|.........||
Mouse   329 YSAVCVYSLGDIDRVF-------RTSS---LKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHP 383

  Fly   474 LMDKAVD--HEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQR 536
            .:.:.|:  .....|:|..: ....|:||.:::... .:.|.|.::.|..|.|:|:|:  ...|.
Mouse   384 EVAQRVEPMGPLKTPLFHSK-YHYQKVVVHRMQASN-GETFHVLYLTTDRGTIHKVVE--SGDQD 444

  Fly   537 HSNLVDIFEASP--HSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYC 597
            ||.:.:|.|..|  .:..|:.::|......|||.:..:|.|:.:.||......|..|:  .||||
Mouse   445 HSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQVPLDMCEVYSGGCHGCLMSRDPYC 509

  Fly   598 GWDKD---------------VNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCF 647
            |||:|               :|...|:     ::..|...   |.:.| :||:.:.....:|:|
Mouse   510 GWDQDRCVSIYSSQRSVLQSINPAEPH-----RECPNPKP---DEAPL-QKVSLARNSRYYLTC- 564

  Fly   648 VKMPEVLRKKQTRWYH-----HSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDG 707
               |...|.....|.|     .|.|.|              ::....:|.:......:|..|
Mouse   565 ---PMESRHATYLWRHEENVEQSCEPG--------------HQSPSCILFIENLTARQYGHY--- 609

  Fly   708 TLLCSYGVTVDAHRCSPPSQKQDYQKIYSHW 738
                         ||.  :|:..|.:...||
Mouse   610 -------------RCE--AQEGSYLREAQHW 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	121/487 (25%)
		PSI	583..>606	CDD:396154	11/39 (28%)
		Ig	632..724	CDD:472250	16/96 (17%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	0/3 (0%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	0/2 (0%)
Sema7a	NP_035482.1	Sema_7A	70..489	CDD:200504	121/487 (25%)
		Cell attachment site. /evidence=ECO:0000255	265..267		0/1 (0%)
		Interaction with integrins. /evidence=ECO:0000250	265..267		0/1 (0%)
		PSI	491..540	CDD:396154	13/53 (25%)
		Ig	547..617	CDD:472250	18/106 (17%)
		Ig strand B	560..564	CDD:409353	1/3 (33%)
		Ig strand C	572..576	CDD:409353	0/3 (0%)
		Ig strand E	594..598	CDD:409353	1/3 (33%)
		Ig strand F	608..613	CDD:409353	3/22 (14%)