Protein Alignment Sema2b and Sema6c

DIOPT Version :9

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_001258953.1
• Gene: Sema6c / 20360
• MGIID: 1338032
• Length: 963
• Species: Mus musculus
• Alignment Length: 584
• Identity: 185/584 - (31%)
• Similarity: 294/584 - (50%)
• Gaps: 91/584 - (15%)

  Fly    61 SLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCT----GSSAAHHLRHHKEHVQDFSCGPLH 121
            |:..|||:|:..::....|....:.|       |..|    |:|.:...|..::.......| |.
Mouse     7 SMPLLLLLLLLSSLPQAQAAFPQDPT-------PLLTSDLQGASPSSWFRGLEDDAVAAELG-LD 63

  Fly   122 YKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLI----LEPTGSDILNCVSKGKREKVE 182
            ::.|.  ..|..|.|.|.|.:|..:|    |:..|.:.|:    |.....|:.||..:||... |
Mouse    64 FQRFL--TLNRTLLVAARDHVFSFDL----QAQEEGEGLVPNKFLTWRSQDMENCAVRGKLTD-E 121

  Fly   183 CRNHIRVIQPMNFNGQKLYVCGTNAHNP--KDYVINANLTHLPRSQYVPGIGL-GIGKCPYDPAD 244
            |.|:|||:.|  :|.|.|..||||:.:|  :.|    .:|.|.:.    |..| |..:||:|...
Mouse   122 CYNYIRVLVP--WNSQTLLACGTNSFSPMCRSY----GITSLQQE----GEELSGQARCPFDATQ 176

  Fly   245 NSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPN 309
            ::.|::.|.       :||:.|.|:|..:|:|::||      .|.:..  .|:.|||||.|.:|:
Mouse   177 STVAIFAEG-------SLYSATAADFQASDAVVYRS------LGPQPP--LRSAKYDSKWLREPH 226

  Fly   310 FVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGK-YMISQNWATYLKARMNCSIS 373
            ||.:.|.||.|||||||.:||....|:..:||||||||.|.||. ..:.::|.::||.|:|||:.
Mouse   227 FVYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVP 291

  Fly   374 SEFPFYFNEIQSVYKMPTD---DTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSN 435
            .:..|||:.:||: ..|.:   .:..:..|||.||.:.|||||::.:.||...|:||||||.:.:
Mouse   292 GDSTFYFDVLQSL-TGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLD 355

  Fly   436 SAWLPVLNSKVPEPRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRD 492
            .||.||...|||.||||:|        .:.:..|||.||.||:.|||:|.||......|:.
Mouse   356 GAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLL---- 416

  Fly   493 VILTKLVVDKIRIDKL---NQEFLVYFVATTSGHIYKIVQFMHYGQRHSN---LVDIFEASPH-- 549
            .:.::.::.::.:|.:   ::...|.|:.:..|.:.|::.  ..||...:   :::..:|..|
Mouse   417 TLTSRALLTQVAVDGMAGPHRNTTVLFLGSNDGTVLKVLP--PGGQSLGSEPIVLEEIDAYSHAR 479

  Fly   550 ---------SEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGWDK 601
                     :..|..:.|..:...|:||....:..:.::.|| |:.:|.| |::  ||||||.:
Mouse   480 CSGKRSPRAARRIIGLELDTEGHRLFVAFPGCIVYLSLSRCA-RHGACQRSCLASLDPYCGWHR 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	160/494 (32%)
		Ig	632..720	CDD:299845
Sema6c	NP_001258953.1	Sema	54..518	CDD:387663	161/503 (32%)
		PSI	519..>540	CDD:214655	10/21 (48%)
		PHA03247	<714..956	CDD:223021

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910