Protein Alignment Sema2b and Sema6b

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_038690.1
• Gene: Sema6b / 20359
• MGIID: 1202889
• Length: 886
• Species: Mus musculus
• Alignment Length: 716
• Identity: 218/716 - (30%)
• Similarity: 333/716 - (46%)
• Gaps: 136/716 - (18%)

  Fly    61 SLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTF 125
            :||..||:|:..             |:.|:.|.|.....:...:|.|:...|   ..||......
Mouse    12 ALSFFLLLLLGV-------------TYGLFPEEPPPLSVAPRDYLSHYPVFV---GSGPGRLTAA 60

  Fly   126 YMDER---------NNALYVGAMDRIFRLNLR-NISQSICERDVLILEPTGSDILNCVSKGKREK 180
            ...|.         |..|::|..|.::::.|. :.|..:..:..|......|||..|..|||:|.
Mouse    61 EGAEDLNIQRVLRVNRTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEG 125

  Fly   181 VECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADN 245
             ||||.::|:  :..:...|:|||:||.||    |.||.: :...|.:.....|:.:|||||...
Mouse   126 -ECRNFVKVL--LLRDESTLFVCGSNAFNP----ICANYS-MDTLQLLGDSISGMARCPYDPKHA 182

  Fly   246 STAVYVENGNPFGLPALYAGTNAEFTKADSVIFRS--DLYNLTNGRKEANFKRTVKYDSKLLDKP 308
            :.|::.:.       .|:..|..:|...|:||:||  |...|          ||||:|||...:|
Mouse   183 NVALFSDG-------MLFTATVTDFLAIDAVIYRSLGDRPTL----------RTVKHDSKWFKEP 230

  Fly   309 NFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGK-YMISQNWATYLKARMNCSI 372
            .||.:.|.|..|||||||.|:|:....|.|.||||||||||.||. .::.:.|.::||||:|||:
Mouse   231 YFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSV 295

  Fly   373 SSEFPFYFNEIQSVYKMPTDDTK--FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSN 435
            ..:..||||.:|:|..:.:...:  ..|.|:|.:|.:.|||||::|:..:.|.|:|:|:||.:..
Mouse   296 PGDSHFYFNVLQAVTGVVSLGGRPVILAVFSTPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPE 360

  Fly   436 SAWLPVLNSKVPEPRPGTC------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVI 494
            |.|.||...:||.||||.|      :|.::.|||.:|||::.|||||:||. ..|:..:..|.::
Mouse   361 SIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDEILNFVKTHPLMDEAVP-SLGHSPWIVRTLM 424

  Fly   495 ---LTKLVVDKIRIDKLNQEFLVYF-----------------VATTSGHIYKIVQFMHY-----G 534
               ||::.|| :.......:.:|:.                 |:.|:|....:.:|..|     |
Mouse   425 RHQLTRVAVD-VGAGPWGNQTIVFLGSEAGTVLKFLVKPNASVSGTTGPSIFLEEFETYRPDRCG 488

  Fly   535 QRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CV--SDPY 596
            :..|       |....:.:..:.|...:|.|..|....|.::.:|.| :.|..|.: |:  .|||
Mouse   489 RPSS-------AGEWGQRLLSLELDAASGGLLAAFPRCVVRVPVARC-QLYSGCMKNCIGSQDPY 545

  Fly   597 CGWDKDVNAC---RPYQLGLL-QDVAN-ETSGICD-TSVLRKK--------------VTSSYGQT 641
            |||..| .:|   ||...... |||:. .|||:.| |.:||..              ||||
Mouse   546 CGWAPD-GSCIFLRPGTSATFEQDVSGASTSGLGDCTGLLRASLSDDRAGLVSVNLLVTSS---- 605

  Fly   642 LHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNE-------GDGG 699
              ::.|| :..|:......|:....|: |...|....:.|..:.|...:|:|:.       |.||
Mouse   606 --VAAFV-VGAVVSGFSVGWFVGLRER-RELARRKDKEAILAHGGSEAVLSVSRLGERRGTGPGG 666

  Fly   700 R 700
            |
Mouse   667 R 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	160/504 (32%)
		PSI	583..>606	CDD:396154	10/25 (40%)
		Ig	632..724	CDD:472250	19/90 (21%)
		Ig strand B	642..646	CDD:409353	0/3 (0%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	1/3 (33%)
		Ig strand F	700..705	CDD:409353	1/1 (100%)
		Ig strand G	717..720	CDD:409353
Sema6b	NP_038690.1	Sema_6B	58..526	CDD:200528	160/501 (32%)
		PSI	527..>556	CDD:396154	12/30 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..677		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..731
		PHA03269	708..>875	CDD:165527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	761..886