DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema6a

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_006525789.1	Gene:	Sema6a / 20358	MGIID:	1203727	Length:	1048	Species:	Mus musculus

Alignment Length:	719	Identity:	212/719 - (29%)
Similarity:	322/719 - (44%)	Gaps:	184/719 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 NNALYVGAMDRIFRLNL--RNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPM 193
            |..|||.|.|.|:.:::  .:..:..|.:. |..:...:|:..|..||| .|.||.|.|:|:  :
Mouse    65 NRTLYVAARDHIYTVDIDTSHTEEIYCSKK-LTWKSRQADVDTCRMKGK-HKDECHNFIKVL--L 125

  Fly   194 NFNGQKLYVCGTNAHNP--KDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNP 256
            ..|...|:||||||.||  ::|.::...|......       |:.:||||....:.|::.:.
Mouse   126 KKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFS-------GMARCPYDAKHANIALFADG--- 180

  Fly   257 FGLPALYAGTNAEFTKADSVIFRS--DLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEF 319
                .||:.|..:|...|:||:||  |...|          ||||:|||.|.:|.||.:.:.|::
Mouse   181 ----KLYSATVTDFLAIDAVIYRSLGDSPTL----------RTVKHDSKWLKEPYFVQAVDYGDY 231

  Fly   320 VYFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPFYFNEI 383
            :||||||.||||...||.|:.|||:|||||.|| :.::.:.|.::||||:|||:..:..||||.:
Mouse   232 IYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNIL 296

  Fly   384 QSVYKMPTDDTKF------YATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVL 442
            |:|    ||..:.      .|||:|..|.:.|||||:||:.||...|.|:||||.:.:|.|.||.
Mouse   297 QAV----TDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVP 357

  Fly   443 NSKVPEPRPGTCHNDTA--------TLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVI---LT 496
            :.:||:||||.|...::        ..||..||||:.|||||:||......| :|.|.::   ||
Mouse   358 DERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRP-WFLRTMVRYRLT 421

  Fly   497 KLVVDKIRIDKLN-----QEFLVYFVATTSGHIYKIVQ------FMHYGQRHSNLVDIFEASPHS 550
            |:.||       |     |...|.|:.:..|.|.|.:.      |:: |......::::.....|
Mouse   422 KIAVD-------NAAGPYQNHTVVFLGSEKGIILKFLARIGSSGFLN-GSLFLEEMNVYNPEKCS 478

  Fly   551 ------EPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGWDKDVNAC 606
                  :.|..|.|...:||||||....|.::.:..| .|:..|.: |::  ||||||.::..:|
Mouse   479 YDGVEDKRIMGMQLDRASGSLYVAFSTCVIKVPLGRC-ERHGKCKKTCIASRDPYCGWVRESGSC 542

  Fly   607 RPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRY 671
                                               .|||...::.          :....|:|
Mouse   543 -----------------------------------AHLSPLSRLT----------FEQDIERG-- 560

  Fly   672 EVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYS 736
                        |..||         |..::|:          |.::......|..:..:.::|.
Mouse   561 ------------NTDGL---------GDCHNSF----------VALNDISTPLPDYEMSFNRVYG 594

  Fly   737 HWCNEF-----------EKYKS--AMKQWQAKQEQCGLKDKTGPISSNGKH-----VNDVF--SN 781
            |..:.:           :.|:|  .|..|....|..|..|..|.:||:...     :.:.:  ||
Mouse   595 HASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRESYLKSN 659

  Fly   782 DALV 785
            |.||
Mouse   660 DQLV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	172/488 (35%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	11/87 (13%)
Sema6a	XP_006525789.1	Sema_6A	48..513	CDD:200527	172/488 (35%)
Sema6a	XP_006525789.1	PSI	514..>546	CDD:366642	12/67 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910