Protein Alignment Sema2b and Sema6a

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: XP_006525789.1
• Gene: Sema6a / 20358
• MGIID: 1203727
• Length: 1048
• Species: Mus musculus
• Alignment Length: 719
• Identity: 212/719 - (29%)
• Similarity: 322/719 - (44%)
• Gaps: 184/719 - (25%)

  Fly   131 NNALYVGAMDRIFRLNL--RNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPM 193
            |..|||.|.|.|:.:::  .:..:..|.:. |..:...:|:..|..||| .|.||.|.|:|:  :
Mouse    65 NRTLYVAARDHIYTVDIDTSHTEEIYCSKK-LTWKSRQADVDTCRMKGK-HKDECHNFIKVL--L 125

  Fly   194 NFNGQKLYVCGTNAHNP--KDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNP 256
            ..|...|:||||||.||  ::|.::...|......       |:.:||||....:.|::.:.
Mouse   126 KKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFS-------GMARCPYDAKHANIALFADG--- 180

  Fly   257 FGLPALYAGTNAEFTKADSVIFRS--DLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEF 319
                .||:.|..:|...|:||:||  |...|          ||||:|||.|.:|.||.:.:.|::
Mouse   181 ----KLYSATVTDFLAIDAVIYRSLGDSPTL----------RTVKHDSKWLKEPYFVQAVDYGDY 231

  Fly   320 VYFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPFYFNEI 383
            :||||||.||||...||.|:.|||:|||||.|| :.::.:.|.::||||:|||:..:..||||.:
Mouse   232 IYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNIL 296

  Fly   384 QSVYKMPTDDTKF------YATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVL 442
            |:|    ||..:.      .|||:|..|.:.|||||:||:.||...|.|:||||.:.:|.|.||.
Mouse   297 QAV----TDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVP 357

  Fly   443 NSKVPEPRPGTCHNDTA--------TLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVI---LT 496
            :.:||:||||.|...::        ..||..||||:.|||||:||......| :|.|.::   ||
Mouse   358 DERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRP-WFLRTMVRYRLT 421

  Fly   497 KLVVDKIRIDKLN-----QEFLVYFVATTSGHIYKIVQ------FMHYGQRHSNLVDIFEASPHS 550
            |:.||       |     |...|.|:.:..|.|.|.:.      |:: |......::::.....|
Mouse   422 KIAVD-------NAAGPYQNHTVVFLGSEKGIILKFLARIGSSGFLN-GSLFLEEMNVYNPEKCS 478

  Fly   551 ------EPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGWDKDVNAC 606
                  :.|..|.|...:||||||....|.::.:..| .|:..|.: |::  ||||||.::..:|
Mouse   479 YDGVEDKRIMGMQLDRASGSLYVAFSTCVIKVPLGRC-ERHGKCKKTCIASRDPYCGWVRESGSC 542

  Fly   607 RPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRY 671
                                               .|||...::.          :....|:|
Mouse   543 -----------------------------------AHLSPLSRLT----------FEQDIERG-- 560

  Fly   672 EVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYS 736
                        |..||         |..::|:          |.::......|..:..:.::|.
Mouse   561 ------------NTDGL---------GDCHNSF----------VALNDISTPLPDYEMSFNRVYG 594

  Fly   737 HWCNEF-----------EKYKS--AMKQWQAKQEQCGLKDKTGPISSNGKH-----VNDVF--SN 781
            |..:.:           :.|:|  .|..|....|..|..|..|.:||:...     :.:.:  ||
Mouse   595 HASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRESYLKSN 659

  Fly   782 DALV 785
            |.||
Mouse   660 DQLV 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	172/488 (35%)
		PSI	583..>606	CDD:396154	9/25 (36%)
		Ig	632..724	CDD:472250	11/91 (12%)
		Ig strand B	642..646	CDD:409353	2/3 (67%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	0/2 (0%)
Sema6a	XP_006525789.1	Sema_6A	48..513	CDD:200527	172/488 (35%)
		PSI	514..>544	CDD:396154	11/65 (17%)