DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema4f

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_035480.3	Gene:	Sema4f / 20355	MGIID:	1340055	Length:	777	Species:	Mus musculus

Alignment Length:	535	Identity:	165/535 - (30%)
Similarity:	254/535 - (47%)	Gaps:	66/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 HYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRN 185
            :|....:|..::.|||||.|.||.|.|....:.....|.::.|   :...||..|||:|. ||.|
Mouse    70 NYSALLVDPASHTLYVGARDSIFALTLPFSGEKPRRIDWMVPE---THRQNCRKKGKKED-ECHN 130

  Fly   186 HIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVY 250
            .|:::...  |...|..|||.|.:||..||:.:     ..|.|..:..|.||||::||..|.||.
Mouse   131 FIQILAIA--NASHLLTCGTFAFDPKCGVIDVS-----SFQQVERLESGRGKCPFEPAQRSAAVM 188

  Fly   251 VENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFE 315
            ...       .||..|...|...:.:|.|:      .||.| ::.||... |..|:.|.||.:..
Mouse   189 AGG-------VLYTATVKNFLGTEPIISRA------VGRAE-DWIRTETL-SSWLNAPAFVAAMV 238

  Fly   316 IG----------EFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNC 370
            :.          :.::|||.|.:....:..:....||||||..|.||:..:.|.|.|:|||.:.|
Mouse   239 LSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLC 303

  Fly   371 SISSEFPFYFNEIQSVYKM---PTDDTK-FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQ 431
            . ..|.......:|.:.::   |...|. ||..|::...|...||||::..:||.|..:|.|:|.
Mouse   304 P-GPEHGRASGVLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFREL 367

  Fly   432 ATSNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPV 487
            ....:..|||::::||:||||.|         ...:.:|||.||.|||.|||||:.|....|.|:
Mouse   368 KHDCNRGLPVMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPL 432

  Fly   488 FFKRDVILTKLVVDKIRIDKLN-QEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSE 551
            ....|....::|..  |:..|: :|:.|.::.|..||:::.|:.   |.:.|.|.|: ...|.::
Mouse   433 LVTTDTAYLRVVAH--RVTSLSGKEYDVLYLGTEDGHLHRAVRI---GAQLSVLEDL-ALFPETQ 491

  Fly   552 PIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWDKDVNACRPY---QL 611
            |:..|.|.|..  |.|.:..:|.|::.:.|. |..||..|:  .||.|.|...::||..:   ..
Mouse   492 PVESMKLYHDW--LLVGSHTEVTQVNTSNCG-RLQSCSECILAQDPVCAWSFRLDACVAHAGEHR 553

  Fly   612 GLLQDVAN-ETSGIC 625
            |::||:.: :.|.:|
Mouse   554 GMVQDIESADVSSLC 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	149/481 (31%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845
Sema4f	NP_035480.3	Sema_4F	58..517	CDD:200522	149/481 (31%)
		PSI	518..569	CDD:279745	16/52 (31%)
		Ig	576..655	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..742
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11483650	775..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910