DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and Sema4d

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001268809.1	Gene:	Sema4d / 20354	MGIID:	109244	Length:	861	Species:	Mus musculus

Alignment Length:	850	Identity:	248/850 - (29%)
Similarity:	368/850 - (43%)	Gaps:	177/850 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEH-- 111
            |||..:|..       |.||:|.:|. |.:|... ..||                      ||
Mouse     3 MCAPVRGLF-------LALVVVLRTA-VAFAPVP-RLTW----------------------EHGE 36

  Fly   112 ---VQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCV 173
               ||....|..:|....|.|..:.|||||.:.:|.:|..|||:...|....:.|...|   .|.
Mouse    37 VGLVQFHKPGIFNYSALLMSEDKDTLYVGAREAVFAVNALNISEKQHEVYWKVSEDKKS---KCA 98

  Fly   174 SKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPK-DYVINANLTHLPRSQYVPGIGLGIGK 237
            .|||.::.||.|:|||:||:  :...||||||||..|. |::...:...|.:|:.      |.|:
Mouse    99 EKGKSKQTECLNYIRVLQPL--SSTSLYVCGTNAFQPTCDHLNLTSFKFLGKSED------GKGR 155

  Fly   238 CPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDS 302
            ||:|||.:.|:|.|..       .||:||:..|..::.:|.|:..::..         || :|..
Mouse   156 CPFDPAHSYTSVMVGG-------ELYSGTSYNFLGSEPIISRNSSHSPL---------RT-EYAI 203

  Fly   303 KLLDKPNFVGSFEI--------GE--FVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMIS 357
            ..|::|:||.:..|        ||  .|||||.|.:|||....|.:..|||||||.|:||...:.
Mouse   204 PWLNEPSFVFADVIQKSPDGPEGEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGGLRTLQ 268

  Fly   358 QNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRD 419
            :.|.::||||:.|| ..:....||.:|.|:.:.....|   |||.||...|.:..||||:|.:..
Mouse   269 KKWTSFLKARLICS-KPDSGLVFNILQDVFVLRAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLAT 332

  Fly   420 INAAFD-GKFKEQAT---SNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNFIRK 471
            :.|.|. ||:.:.||   |::.|:. .|..||.||||.|         :..:..|||..|.|::.
Mouse   333 VEAVFSRGKYMQSATVEQSHTKWVR-YNGPVPTPRPGACIDSEARAANYTSSLNLPDKTLQFVKD 396

  Fly   472 HPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFL-VYFVATTSGHIYKIVQFMHYGQ 535
            |||||.:|......|...|:||..|::|||  |...|:..|. |.|::|..|.::|.|..    .
Mouse   397 HPLMDDSVTPIDNRPKLIKKDVNYTQIVVD--RTQALDGTFYDVMFISTDRGALHKAVIL----T 455

  Fly   536 RHSNLVDIFEASPHSEPIREMTLSHKTGS--LYVATDHQVKQIDIAMCARRYDSCFRCV--SDPY 596
            :..::::..:....|||:..:.||.|.|.  :|..::..|.|..:|.| .::.||..||  .|||
Mouse   456 KEVHVIEETQLFRDSEPVLTLLLSSKKGRKFVYAGSNSGVVQAPLAFC-EKHGSCEDCVLARDPY 519

  Fly   597 CGWDKDVNAC------RPYQLGLLQDVANETSGICDTSVLRKKVTS---SYGQTLHLSCFVK--M 650
            |.|...:.||      .....|.:||::.:||...|.|  ::....   .:|.|..|.||.|  :
Mouse   520 CAWSPAIKACVTLHQEEASSRGWIQDMSGDTSSCLDKS--KESFNQHFFKHGGTAELKCFQKSNL 582

  Fly   651 PEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLD--------G 707
            ..|:.|.|..           |::....||.......|::..:::||.|.|....:        .
Mouse   583 ARVVWKFQNG-----------ELKAASPKYGFVGRKHLLIFNLSDGDSGVYQCLSEERVRNKTVS 636

  Fly   708 TLLCSYGVTVDAHRCSPPS-QKQDYQKIYSHWCNEFEKYKSAM-------------KQWQAKQEQ 758
            .||..:.:.|.....:||| ..:|.|       .|..|..|.|             ..|......
Mouse   637 QLLAKHVLEVKMVPRTPPSPTSEDAQ-------TEGSKITSKMPVASTQGSSPPTPALWATSPRA 694

  Fly   759 CGLKDKTGPISSNGKH------VNDVFSNDALVXPRKYLYSFEFLSSATEGVASAHRKLYIFVFV 817
            ..|.    |.||:|..      :|.|        |:.:.....:|.|:...:..: ..|:|||..
Mouse   695 ATLP----PKSSSGTSCEPKMVINTV--------PQLHSEKTVYLKSSDNRLLMS-LLLFIFVLF 746

  Fly   818 LTIFA 822
            |.:|:
Mouse   747 LCLFS 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	164/488 (34%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	20/100 (20%)
Sema4d	NP_001268809.1	Sema_4D	31..501	CDD:200520	171/527 (32%)
		PSI	503..548	CDD:396154	15/45 (33%)
		Ig	563..646	CDD:416386	19/93 (20%)
		Ig strand B	569..577	CDD:409353	3/7 (43%)
		Ig strand C	583..589	CDD:409353	1/5 (20%)
		Ig strand C'	591..594	CDD:409353	0/13 (0%)
		Ig strand D	600..604	CDD:409353	2/3 (67%)
		Ig strand E	607..614	CDD:409353	1/6 (17%)
		Ig strand F	620..629	CDD:409353	2/8 (25%)
		Ig strand G	633..646	CDD:409353	2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..709		15/70 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.870