Protein Alignment Sema2b and Sema4c

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: XP_006495867.1
• Gene: Sema4c / 20353
• MGIID: 109252
• Length: 943
• Species: Mus musculus
• Alignment Length: 683
• Identity: 209/683 - (30%)
• Similarity: 312/683 - (45%)
• Gaps: 103/683 - (15%)

  Fly    84 ENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLR 148
            |..|||.......:|.......|..:..:|||       .|..:.|.:..|||||.:.:|..::
Mouse   131 EMWWNLVPRKTVSSGELVTVVRRFSQTGIQDF-------LTLTLTEHSGLLYVGAREALFAFSV- 187

  Fly   149 NISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDY 213
               :::..:..:..|......:.|..|||..:.||.|.||.:||  :|...||||||.|..||..
Mouse   188 ---EALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQP--YNSSHLYVCGTYAFQPKCT 247

  Fly   214 VINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIF 278
            .||.....|.|:::..    |.||||||||...|.:.|:.       .||:.|...|...:.||.
Mouse   248 YINMLTFTLDRAEFED----GKGKCPYDPAKGHTGLLVDG-------ELYSATLNNFLGTEPVIL 301

  Fly   279 RSDLYNLTNGRKEANFKRTVK--YDSKLLDKPNFVGSF----EIGEF------VYFFFREHAVEY 331
            |   |..|:        .::|  |.:..|::|:||||.    .:|.|      :||||.|.||||
Mouse   302 R---YMGTH--------HSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEY 355

  Fly   332 INCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKM---PTDD 393
            ....:.|.:|||||||.|.||...:.:.|.|:||||:.|| :.::..|||::::|:.:   ...:
Mouse   356 DCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCS-APDWKVYFNQLKAVHTLRGASWHN 419

  Fly   394 TKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC---- 454
            |.|:..|......:..||||.|.:..|...|:|.:||.:.....|.. ....||.||||:|
Mouse   420 TTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWAR-YTDPVPSPRPGSCINNW 483

  Fly   455 HND-----TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKI-RIDKLNQEFL 513
            |.|     :..|||:.||||:|||||:..|....|.|:..|::...|.:|.|:: .:|  ...:.
Mouse   484 HRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLD--GATYT 546

  Fly   514 VYFVATTSGHIYKIVQ---FMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQ 575
            |.|:.|..|.:.|.|.   ::|..:.    :.:|:    .||:..:.||.....|:..:..|:.|
Mouse   547 VLFIGTGDGWLLKAVSLGPWIHMVEE----LQVFD----QEPVESLVLSQSKKVLFAGSRSQLVQ 603

  Fly   576 IDIAMCARRYDSCFRCV--SDPYCGWDKDVNACRPYQLG-----LLQDVAN-ETSGICDTSVLR- 631
            :.:|.|. :|..|..||  .||||.|:.:.:.|.....|     |:|.||| :||.:|:...::
Mouse   604 LSLADCT-KYRFCVDCVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKK 667

  Fly   632 -----KKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYI-DTNEGGLVL 690
                 |.:|...|..|.|.|.:..    ......|...|.:....:    |..:: ||....||:
Mouse   668 VRSIPKNITVVSGTDLVLPCHLSS----NLAHAHWTFGSQDLPAEQ----PGSFLYDTGLQALVV 724

  Fly   691 LAVNEGDGGRYDSYLD--GTLLC--SYGVTVDA 719
            :|......|.|..|.:  ||.|.  ||.|.|.|
Mouse   725 MAAQSRHSGPYRCYSEEQGTRLAAESYLVAVVA 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	154/486 (32%)
		PSI	583..>606	CDD:396154	9/24 (38%)
		Ig	632..724	CDD:472250	25/93 (27%)
		Ig strand B	642..646	CDD:409353	2/3 (67%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	1/3 (33%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	2/3 (67%)
Sema4c	XP_006495867.1	Sema_4C	151..607	CDD:200519	158/502 (31%)
		PSI	608..>637	CDD:214655	11/29 (38%)
		Ig	673..757	CDD:472250	24/91 (26%)
		Ig strand B	683..687	CDD:409456	2/3 (67%)
		Ig strand C	695..699	CDD:409456	0/3 (0%)
		Ig strand E	720..724	CDD:409456	1/3 (33%)
		Ig strand F	734..739	CDD:409456	1/4 (25%)
		Ig strand G	751..754	CDD:409456	1/2 (50%)