DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema3e

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_035478.2	Gene:	Sema3e / 20349	MGIID:	1340034	Length:	775	Species:	Mus musculus

Alignment Length:	769	Identity:	219/769 - (28%)
Similarity:	329/769 - (42%)	Gaps:	155/769 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 HKEHVQ-------DFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPT 165
            |||.::       ....|.|...|..:||....|:||..|.::.|||..:|....|   :....|
Mouse    37 HKELLELNRTSIFQSPLGFLDLHTMLLDEYQERLFVGGRDLVYSLNLERVSDGYRE---IYWPST 98

  Fly   166 GSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINAN------LTHLP- 223
            ...:..|:.||| :..||.|:|||:.  ::|...|..|.|.|.:|....|...      |.||.
Mouse    99 AVKVEECIMKGK-DANECANYIRVLH--HYNRTHLLTCATGAFDPHCAFIRVGHHSEEPLFHLES 160

  Fly   224 -RSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTN 287
             ||:      .|.|:||:||  ||:.|....||     .|:||..:::...||.||||
Mouse   161 HRSE------RGRGRCPFDP--NSSFVSTLVGN-----ELFAGLYSDYWGRDSAIFRS------- 205

  Fly   288 GRKEANFKRTVKYDSKLLDKPNFVGSFEIGE-------FVYFFFREHAVEYINCGKAVYSRVARV 345
             ..:....||...|.:||.:|.||||:.|.:       .:||||.|.|:|..|....:|:||.|:
Mouse   206 -MGKLGHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKMYFFFTEKALEAENNAHTIYTRVGRL 269

  Fly   346 CKNDRGGKYMISQNWATYLKARMNCSI--SSEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTN 405
            |.||.||:.::...|:|:||||:.||:  .:....||:|::.|:.:||.|.|   .:..|.|.:|
Mouse   270 CVNDMGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDPKNPVIFGLFNTTSN 334

  Fly   406 GLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC--------HNDTATLP 462
            ...|.|||.|.:..|..||:|.:..:......| .:...|||.||||:|        :..|...|
Mouse   335 IFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHW-SLYEGKVPYPRPGSCASKVNGGKYGTTKDYP 398

  Fly   463 DSVLNFIRKHPLMDKAVDHEFGNPVFFKRD--VILTKLVVDKIRIDKLNQEFLVYFVATTSGHIY 525
            |..:.|.|.||||.:.:......|:..|.|  ..|.:|.||  |::..:.::.|.|:.|.:|.:.
Mouse   399 DDAIRFARMHPLMYQPIKPVHKKPILVKTDGKYNLRQLAVD--RVEAEDGQYDVLFIGTDTGIVL 461

  Fly   526 KIVQFMHYGQR----HSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYD 586
            |::..  |.|.    ...:::..:......||..|.:|.|...||:.:...|.|:....|.....
Mouse   462 KVITI--YNQETEWMEEVILEELQIFKDPAPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGS 524

  Fly   587 SCFRC--VSDPYCGWDKDVNACRPYQLGL-------LQDV-----ANETSG--ICDTSVLRKKVT 635
            :|..|  ..||||.|| .::..|.|..|.       .|||     |.:..|  ....::.|.:..
Mouse   525 ACADCCLARDPYCAWD-GISCSRYYPTGAHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDRTEER 588

  Fly   636 SSYG----QTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYID---TNEGGLVLLAV 693
            .:||    .|| |.|   .|..|:.| ..|:   .:||| :||....|..|   ..:.||:.|.|
Mouse   589 LAYGIESNSTL-LEC---TPRSLQAK-VIWF---VQKGR-DVRKEEVKTDDRVVKMDLGLLFLRV 644

  Fly   694 NEGDGGRY------DSYLDGTLLCSYGVTVDAHR------------------CSP---------P 725
            .:.|.|.|      .:::......:..| |:.|:                  |.|         |
Mouse   645 RKSDAGTYFCQTVEHNFVHTVRKITLEV-VEEHKVEGMFHKDHEEERHHKMPCPPLSGMSQGTKP 708

  Fly   726 SQKQDYQKI-YSH-----------WCNE--FEKYKSAMKQWQ-AKQEQCGLKDK 764
            ..|:..|.| ||:           ||.:  .:|.|.:..:|: |..::..|:.|
Mouse   709 WYKEFLQLIGYSNFQRVEEYCEKVWCTDKKRKKLKMSPSKWKYANPQEKRLRSK 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	154/492 (31%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	26/100 (26%)
Sema3e	NP_035478.2	Sema_3E	49..519	CDD:200514	155/501 (31%)
		PSI	518..566	CDD:214655	15/48 (31%)
		Ig_Semaphorin_classIII	585..675	CDD:143279	26/99 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910