DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema3c

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_038685.3	Gene:	Sema3c / 20348	MGIID:	107557	Length:	751	Species:	Mus musculus

Alignment Length:	798	Identity:	217/798 - (27%)
Similarity:	330/798 - (41%)	Gaps:	178/798 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CCTGSSAAH--------HLRHHK-------EHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFR 144
            |..|||...        .||..|       .|.|      |.|:...|||..:.:|||:.|.|..
Mouse    18 CVRGSSQPQARVYLTFDELRETKTSEYFSLSHQQ------LDYRILLMDEDQDRIYVGSKDHILS 76

  Fly   145 LNLRNISQSICERDVLILEPTGS-DILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAH 208
            ||:.||||    ..:.:..|..: .:..|...||.....|.|.:||||  .||...|||||:.|.
Mouse    77 LNINNISQ----EPLSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQ--TFNRTHLYVCGSGAF 135

  Fly   209 NPKDYVINANLTHLPRSQYVPG--------IGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAG 265
            :|.       .|:|.|.:....        ...|.|:|.::|..|:.:|.:..       .|::|
Mouse   136 SPV-------CTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINE-------ELFSG 186

  Fly   266 TNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGE-------FVYFF 323
            ...:|...|:.||||    ||    :.|..||.:::||.|.:|.||.:..|.:       .||||
Mouse   187 MYIDFMGTDAAIFRS----LT----KRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFF 243

  Fly   324 FREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEF--PFYFNEIQSV 386
            |:|...:.....|.::|.:||:|.||.||:..:...|.|:||||:.||::.|.  ..:|:|::.|
Mouse   244 FKERLTDNNRSTKQIHSMIARICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDV 308

  Fly   387 YKMPTDD---TKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPE 448
            :.:.||:   |..|..|||:::...|||||.|.:.||...|:|.|..:...|.. |.....::|.
Mouse   309 FLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQ-LISYQGRIPY 372

  Fly   449 PRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFK--RDVILTKLVVDKI 503
            ||||||        ...|...||.|:.|||.||||..::......|:..:  .|...||:.||
Mouse   373 PRPGTCPGGAFTPNMRTTKDFPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVD-- 435

  Fly   504 RIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLV-DIFEASPHSEPIREMTLSHKTGSLYV 567
            |::..:..:.|.|:.|..|.:.|:|...........|: :..|...:..||..|.:|.|...|||
Mouse   436 RVNAADGRYHVLFLGTDRGTVQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYV 500

  Fly   568 ATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWD-----------------KDV------NACR 607
            :::..|.|:.:..|.....:|..|  ..||||.||                 :||      ..||
Mouse   501 SSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCR 565

  Fly   608 PYQLGLLQDVANETS-GICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRY 671
            .:.|...::.|.... |:.:.|..             |.|..|.|:.    ..:|.....:..|.
Mouse   566 GFNLKAYRNAAEIVQYGVRNNSTF-------------LECAPKSPQA----SIKWLLQKDKDRRK 613

  Fly   672 EVRYTPTKYIDTNEGGLVLLAVNEGDGGRY------DSY------LDGTLLCSYGVTVDAHRCSP 724
            ||:.. .:.|.|:: ||::.:|.:.|.|.|      :|:      ::..:|.|..|.|...:.||
Mouse   614 EVKLN-ERIIATSQ-GLLIRSVQDSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSP 676

  Fly   725 ----------PSQKQDYQKIYSH--------WCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSN 771
                      |...:|....:||        :|      |...:|.|..:|...::...|.:.
Mouse   677 WTWAGSVRALPFHPKDILGAFSHSEMQLINQYC------KDTRQQQQLGEEPQKMRGDYGKLK-- 733

  Fly   772 GKHVNDVFSNDALVXPRK 789
                       ||:..||
Mouse   734 -----------ALINSRK 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	154/490 (31%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	21/99 (21%)
Sema3c	NP_038685.3	Sema_3C	45..514	CDD:200512	156/505 (31%)
		PSI	513..550	CDD:214655	9/36 (25%)
		Ig_Semaphorin_classIII	575..664	CDD:143279	21/107 (20%)
		IG_like	579..653	CDD:214653	19/92 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910