DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and smp-2

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_491197.3	Gene:	smp-2 / 183905	WormBaseID:	WBGene00004890	Length:	649	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	152/567 - (26%)
Similarity:	238/567 - (41%)	Gaps:	110/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 HLRHHKEHVQDFSCGPLHYKTFYMDERN----------NALYVGAMDRIF--------------R 144
            |||     :..|...||...:|:..:.|          .||..||.:::.              |
Worm     3 HLR-----IFIFLLAPLGSASFFNPDTNVSRVDVSHLSRALSYGANEKLVILHKLPGEYVLLGGR 62

  Fly   145 LNLRNIS-QSICERDVLILEPTGSD--ILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTN 206
            .::.||| .|:.|  :...|.|.||  ..||.:. .:....|.|.||..  .......|.:|||:
Worm    63 NHVYNISISSMLE--IARYEWTSSDEARTNCAAI-SQTPASCENFIRTY--FELTNDTLILCGTH 122

  Fly   207 AHNPKDYVI---NANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYV-ENGNPFGLPALYAGTN 267
            |..|.....   ||....|..:         :|..|.| || |||.:: .|.|      :.....
Worm   123 ALQPTCAEFRKGNAKPQRLISA---------VGMSPID-AD-STAPFIRSNEN------IITVNV 170

  Fly   268 AEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYI 332
            ||.:.::.::.|.::..:..|.:.....||.:..|. .::.||:...::.:.|.|||.|..:|..
Worm   171 AELSSSEPLLVRRNVIKMWKGIENDVILRTPRGLSS-FEQANFLSMHKVKKEVLFFFSESPMETE 234

  Fly   333 NCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSI--SSEFPFYFNEIQSVYKMPTDDTK 395
            .||....:||.|||::|.||:...::.|::|.|||:.|||  :....||||:...|.:.|   |.
Worm   235 GCGLHKVARVGRVCEDDPGGRLSYNKEWSSYEKARIECSIEETDTDTFYFNQFAGVAESP---TS 296

  Fly   396 FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCH--NDT 458
            ||..|.:...|:..||:|.|..:.|:.:|...:||..                  |.||.  ||.
Worm   297 FYGAFRSQLAGIGASAICKYSKKVISGSFASGYKEST------------------PDTCSRANDI 343

  Fly   459 ATLPDSVLNFIRKHPLMDKAVDHEFGNP--VFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTS 521
                 ..|:.||..||:.:.:.   .||  :|..:|..:..|..:..| |..|:.:.:.:|||..
Worm   344 -----EELSRIRLKPLIKQKIS---ANPIYIFHGKDRFVHVLAQEDTR-DLSNRAYDILYVATNL 399

  Fly   522 GHIYKI-VQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTG--SLYVATDHQVKQIDIAMCAR 583
            |:|.|| |.......||:..:.:.   |.:..|.:|:|..|..  .|.|.|:..|.::..|.| .
Worm   400 GNILKIVVPSTDKTGRHAVTLKVL---PTNSKIVDMSLYSKNNLEELIVITEQSVLKVPTATC-H 460

  Fly   584 RYDSCFRCVS--DPYCGWDKDVNA--CRPYQLGLLQDVANETSGICD 626
            ...:|..|::  ||:|.|...|:.  .|..|    :..|::.||.||
Worm   461 LASNCAECLAHGDPHCAWADGVDCIDIRTDQ----RKSASQDSGTCD 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	131/498 (26%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845
smp-2	NP_491197.3	Sema	47..429	CDD:214747	116/437 (27%)
smp-2	NP_491197.3	Sema	<390..478	CDD:387663	26/91 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910