DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and smp-1

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001379344.1	Gene:	smp-1 / 173351	WormBaseID:	WBGene00004889	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	167/509 - (32%)
Similarity:	264/509 - (51%)	Gaps:	62/509 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 HYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRN 185
            |:|....|  .::|.|||.:.::.|:|..:|.:    ..:..:|....|..|:.||| .|.:|:|
Worm    54 HFKLLAAD--GDSLLVGARNAVYNLSLSTLSVN----HKIDWKPPAEHIEECIMKGK-SKTDCQN 111

  Fly   186 HIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGL-------GIGKCPYDPA 243
            :|||:...: .|..| ||||:|.:||           .|...|...|:       |.|..||||.
Worm   112 YIRVLARKS-AGVSL-VCGTHAFSPK-----------CREYTVTEFGIRNTRQFDGQGISPYDPK 163

  Fly   244 DNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKP 308
            .||:|:||...|     .|:..|..:|...|::|:|..:....:.:..||. ||..||:::|:.|
Worm   164 HNSSALYVPGTN-----QLFVATVTDFVGNDALIYRKTIDETPSSKSAANI-RTQSYDARVLNAP 222

  Fly   309 NFVGSFEIGEFVYFFFREHAVEYI--NCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCS 371
            |||.:|...|.|||:|||.|.|.|  |....:|:|||||||||:||....::.|.:|||||:|||
Worm   223 NFVATFAYKEHVYFWFREIASEAIDNNEEPQIYARVARVCKNDKGGARPANERWTSYLKARLNCS 287

  Fly   372 I-SSEFPFYFNEIQSVYKMPTD----DTKFYATFTTNTNGLIGSAVCSYDIRDINAAFD-GKFKE 430
            : |...||||||:::| ..|.|    :...|..|:|..:.:..||||.:.::.|...|| |.||.
Worm   288 LPSGSSPFYFNELKAV-SDPIDAGNNNHVVYTVFSTPDSDVRMSAVCKFSMKKIREEFDNGTFKH 351

  Fly   431 QATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFF----KR 491
            |..:.|.|:....::||:||||:|..|:..||::.::||..|||:.:.:. ....|:..    :.
Worm   352 QNNAQSMWMAFNRNEVPKPRPGSCSPDSTKLPENTVSFILHHPLLHRPIP-SVAAPLLVEGADRA 415

  Fly   492 DVILTKL-VVDKIR-IDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSEPIR 554
            |  ||:: |:.::| :...|.:.|  |:.|:.|.:.|:|:.      ..|...|..|:.....:.
Worm   416 D--LTQITVLPRVRAVGGHNYDIL--FIGTSDGKVLKVVEV------DGNATVIQSATVFQRGVP 470

  Fly   555 EMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWDKDVNAC 606
            .:.|.....|:.:.:..::..:.:..||:: .||.:||  .||:|.||..:..|
Worm   471 IVNLLTTKESVVIVSADEIASLPVHNCAQQ-TSCSKCVQLQDPHCAWDSSIARC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	155/478 (32%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845
smp-1	NP_001379344.1	Sema_1A	49..497	CDD:200498	155/480 (32%)
smp-1	NP_001379344.1	PSI	496..547	CDD:214655	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007625
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010