Protein Alignment Sema2b and Sema3d

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_083158.3
• Gene: Sema3d / 108151
• MGIID: 1860118
• Length: 777
• Species: Mus musculus
• Alignment Length: 777
• Identity: 217/777 - (27%)
• Similarity: 345/777 - (44%)
• Gaps: 163/777 - (20%)

  Fly   108 HKEHVQDFSCGP-------LHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPT 165
            :|:.:...:|.|       |.::|..:||....|.:||.|.:|.|:|.:::::..:    |..|.
Mouse    49 YKDLLLSNTCIPFLGSSEGLDFQTLLLDEERGILLLGAKDHVFLLSLVDLNKNFKK----IYWPA 109

  Fly   166 GSDILN-CVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPK-DYV-INANLTHLPRSQY 227
            ..:.:. |...||....||.|.|||:||  :|...:|||||.|.:|. .|: :.||...|.....
Mouse   110 AKERVELCKLAGKDANAECANFIRVLQP--YNKTHVYVCGTGAFHPLCGYIDLGANKEELIFKLD 172

  Fly   228 VPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRS-----DLYNLTN 287
            ...:..|..|||:||.....:|..:.       .||:||.::|...|:...||     |.:::
Mouse   173 THNLESGRLKCPFDPQQPFASVMTDE-------HLYSGTASDFLGKDTAFTRSLGLMQDHHSI-- 228

  Fly   288 GRKEANFKRTVKYDSKLLDKPNFVGSFEI-------GEFVYFFFREHAVEYINCGKAVYSRVARV 345
                    ||...:...|:...|:|:|.|       .:.:||||||.:.|.....:::.|||.||
Mouse   229 --------RTDISEHHWLNGAKFIGTFPIPDTYNPDDDKIYFFFRESSQEGSTSDRSILSRVGRV 285

  Fly   346 CKNDRGGKYMISQNWATYLKARMNCSI--SSEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTN 405
            ||||.||:..:...|.|:||||:.|||  |.....:|:|:|.:|.:||.|.:   .|..|||.::
Mouse   286 CKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTHFDELQDIYLLPTRDERNPVVYGVFTTTSS 350

  Fly   406 GLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHN--------DTATLP 462
            ...|||||.|.:.||.|.|:|.:..:.:::..|:. .:.::|.||||||.:        .|...|
Mouse   351 IFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQ-YDGRIPYPRPGTCPSKTYDPLIKSTRDFP 414

  Fly   463 DSVLNFIRKHPLMDKAVDHEFGNPVFFKR---DVILTKLVVDKIRIDKLNQEFLVYFVATTSGHI 524
            |.|::|||:||:|.|:|....|.|. |||   |..||::|||.:..:  :.::.|.|:.|..|.:
Mouse   415 DDVISFIRRHPVMYKSVYPVAGAPT-FKRINVDYRLTQIVVDHVVAE--DGQYDVMFLGTDIGTV 476

  Fly   525 YKIVQFMHYGQRHSNLVDI----FEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRY 585
            .|:|..   .:...|:.::    .:...|...|..|.||.|...|||.:...:.|:.:..|....
Mouse   477 LKVVSI---SKEKWNMEEVVLEELQVFKHPTAILNMELSLKQQQLYVGSWDGLVQLSLHRCDTYG 538

  Fly   586 DSCFRC--VSDPYCGWDKDVNACRPY--------------------QLGLLQD-VANETSGICDT 627
            .:|..|  ..||||.||.  |||..|                    |...::| :::||:   |.
Mouse   539 KACADCCLARDPYCAWDG--NACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETA---DE 598

  Fly   628 SVLRKKVTSSYG---QTLHLSCFVKMPEVLRKKQTRWY-HHSTEKGRYEVRYTPTKYIDTNEGGL 688
            .|:       :|   .:..|.|..|.    ::....|| ..|.::.|.|::  |.:.|...:.||
Mouse   599 KVI-------FGIEFNSTFLECIPKS----QQASVEWYIQRSGDEHREELK--PDERIIKTDYGL 650

  Fly   689 VLLAVNEGDGGRY----------------------DSYLDGTLLCSY--GVTVDAHRCSPPSQKQ 729
            ::.::.:.|.|.|                      :..::.|....|  |...|....|....|
Mouse   651 LIRSLQKKDSGMYYCKAQEHTFIHTIVKLTLNVIENEQMENTQRAEYQEGQVKDLLAESRLRYK- 714

  Fly   730 DYQKIYS-------HWCNEF---EKYKSAMK---QWQAKQEQCGLKDKTGPISSNGKHVNDV 778
            ||.:|.|       .:|.:.   ||.:...|   :|:..||   :|.|     .|.:|..|:
Mouse   715 DYIQILSSPNFSLDQYCEQMWYKEKRRQRNKGSPKWKHMQE---MKKK-----RNRRHHRDL 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	157/493 (32%)
		PSI	583..>606	CDD:396154	9/24 (38%)
		Ig	632..724	CDD:472250	20/119 (17%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/26 (4%)
		Ig strand G	717..720	CDD:409353	1/2 (50%)
Sema3d	NP_083158.3	Sema_3D	61..534	CDD:200513	157/502 (31%)
		PSI	533..570	CDD:214655	13/38 (34%)
		Ig_Sema3	595..686	CDD:409455	19/106 (18%)
		Ig strand A	595..601	CDD:409455	2/8 (25%)
		Ig strand B	606..614	CDD:409455	1/7 (14%)
		Ig strand C	620..626	CDD:409455	1/5 (20%)
		Ig strand C'	628..631	CDD:409455	1/2 (50%)
		Ig strand D	641..645	CDD:409455	1/3 (33%)
		Ig strand E	648..655	CDD:409455	2/6 (33%)
		Ig strand F	661..670	CDD:409455	2/8 (25%)
		Ig strand G	673..686	CDD:409455	0/12 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..777		9/37 (24%)