DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and SEMA3C

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001337049.1	Gene:	SEMA3C / 10512	HGNCID:	10725	Length:	769	Species:	Homo sapiens

Alignment Length:	779	Identity:	215/779 - (27%)
Similarity:	325/779 - (41%)	Gaps:	163/779 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 TGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLI 161
            |.:|....|.||          ||.|:...|||..:.:|||:.|.|..||:.||||..    :.:
Human    57 TKTSEYFSLSHH----------PLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEA----LSV 107

  Fly   162 LEPTGS-DILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRS 225
            ..|..: .:..|...||.....|.|.:||||  .||...|||||:.|.:|.       .|:|.|.
Human   108 FWPASTIKVEECKMAGKDPTHGCGNFVRVIQ--TFNRTHLYVCGSGAFSPV-------CTYLNRG 163

  Fly   226 QYVPG--------IGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDL 282
            :....        ...|.|:|.::|..|:.:|.:..       .|::|...:|...|:.||||
Human   164 RRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINE-------ELFSGMYIDFMGTDAAIFRS-- 219

  Fly   283 YNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGE-------FVYFFFREHAVEYINCGKAVYS 340
              ||    :.|..||.:::||.|.:|.||.:..|.:       .|||||:|...:.....|.::|
Human   220 --LT----KRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHS 278

  Fly   341 RVARVCKNDRGGKYMISQNWATYLKARMNCSISSEF--PFYFNEIQSVYKMPTDD---TKFYATF 400
            .:||:|.||.||...:...|.|:||||:.||::.|.  ..:|:|::.|:.:.||:   |..|..|
Human   279 MIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIF 343

  Fly   401 TTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC--------HND 457
            ||:::...|||||.|.:.||...|:|.|..:...|.. |.....::|.||||||        ...
Human   344 TTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQ-LISYQGRIPYPRPGTCPGGAFTPNMRT 407

  Fly   458 TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFK--RDVILTKLVVDKIRIDKLNQEFLVYFVATT 520
            |...||.|:.|||.||||..::......|:..:  .|...||:.||  |::..:..:.|.|:.|.
Human   408 TKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVD--RVNAADGRYHVLFLGTD 470

  Fly   521 SGHIYKIVQFMHYGQRHSNLV-DIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARR 584
            .|.:.|:|...........|: :..|...:..||..|.:|.|...|||:::..|.|:.:..|...
Human   471 RGTVQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIY 535

  Fly   585 YDSCFRC--VSDPYCGWD-----------------KDV------NACRPYQLGLLQDVANETSGI 624
            ..:|..|  ..||||.||                 :||      ..||.:.|...::.|.
Human   536 GTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAE----- 595

  Fly   625 CDTSVLRKKVTSSYG---QTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEG 686
                      ...||   .|..|.|..|.|:.    ..:|.....:..|.||:.. .:.|.|::
Human   596 ----------IVQYGVKNNTTFLECAPKSPQA----SIKWLLQKDKDRRKEVKLN-ERIIATSQ- 644

  Fly   687 GLVLLAVNEGDGGRY------DSY------LDGTLLCSYGVTVDAHRCSP----------PSQKQ 729
            ||::.:|...|.|.|      :|:      ::..:|.|..|.|...:.||          |...:
Human   645 GLLIRSVQGSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWASSVRALPFHPK 709

  Fly   730 DYQKIYSH----WCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALVXPRK 789
            |....:||    ..|::  .|...:|.|...|...::...|.:.             ||:..||
Human   710 DIMGAFSHSEMQMINQY--CKDTRQQHQQGDESQKMRGDYGKLK-------------ALINSRK 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	154/490 (31%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	24/102 (24%)
SEMA3C	NP_001337049.1	Sema_3C	63..532	CDD:200512	158/509 (31%)
		PSI	531..568	CDD:214655	9/36 (25%)
		Ig_Semaphorin_classIII	593..682	CDD:143279	22/109 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910