DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and SEMA4B

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001310963.1	Gene:	SEMA4B / 10509	HGNCID:	10730	Length:	847	Species:	Homo sapiens

Alignment Length:	832	Identity:	219/832 - (26%)
Similarity:	329/832 - (39%)	Gaps:	209/832 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFY 126
            |..|||:|:.|..         ..||.|........||.....||...||:.       :|....
Human    26 LLLLLLLLLLQPP---------PPTWALSPRISLPLGSEERPFLRFEAEHIS-------NYTALL 74

  Fly   127 MDERNNALYVGAMDRIFRL--NLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRV 189
            :......|||||.:.:|.|  ||..:...  |...|:..........|..|||..:.:|:|:|::
Human    75 LSRDGRTLYVGAREALFALSSNLSFLPGG--EYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKI 137

  Fly   190 IQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGL---GIGKCPYDPADNSTAVYV 251
            :.|:  :|..|:.|||.|.:|....||.....|.|.:  .|..|   |.|:||:||...|||:.|
Human   138 LLPL--SGSHLFTCGTAAFSPMCTYINMENFTLARDE--KGNVLLEDGKGRCPFDPNFKSTALVV 198

  Fly   252 ENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEI 316
            :.       .||.||.:.|...|..|.||.....|......|:          |..|.||.|..|
Human   199 DG-------ELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNW----------LQDPAFVASAYI 246

  Fly   317 GEF----------VYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCS 371
            .|.          :||||.|...|:......:.||:||:||.|.||:.::.|.|.::|||::.||
Human   247 PESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCS 311

  Fly   372 ISSE-FPFYFNEIQSVYKM---PTD--DTKFYATFTT--NTNGLIGSAVCSYDIRDINAAFDGKF 428
            ...: ||  ||.:|.|:.:   |.|  ||.||..||:  :.....|||||.:.::|:...|.|.:
Human   312 RPDDGFP--FNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLY 374

  Fly   429 KEQATSNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNFIRKHPLMDKAVDHEFG 484
            ||.......|..|.: .||.||||.|         .|.:..|||.||||::.|.|||..|....
Human   375 KEVNRETQQWYTVTH-PVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVRSRM- 437

  Fly   485 NPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPH 549
              :..:......::.|.  |:..|:..:.|.|:.|..|.::|.|.   .|.| .::::..:....
Human   438 --LLLQPQARYQRVAVH--RVPGLHHTYDVLFLGTGDGRLHKAVS---VGPR-VHIIEELQIFSS 494

  Fly   550 SEPIREMTL-SHKT---------GSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWD-- 600
            .:|::.:.| :|:.         |.||.|:...|.|:.:|.|: .|.||..|:  .||||.|.
Human   495 GQPVQNLLLDTHRVSRPTRNPGRGLLYAASHSGVVQVPMANCS-LYRSCGDCLLARDPYCAWSGS 558

  Fly   601 --KDVN------ACRPYQLGLLQDVANETS-GICDTSVLRKKVTSSYGQTLHLSC---------- 646
              |.|:      |.||:    :||:...:: .:|..|.:   |:.|:..|....|
Human   559 SCKHVSLYQPQLATRPW----IQDIEGASAKDLCSASSV---VSPSFVPTGEKPCEQVQFQPNTV 616

  Fly   647 -FVKMPEVLRKKQTR-WYHH--------------------------------STEKGRYEV--RY 675
             .:..| :|....|| |..:                                |.|:|..::  .|
Human   617 NTLACP-LLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLEEGFQQLVASY 680

  Fly   676 TPTKYID-----TNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPS-QKQDYQKI 734
            .|....|     |:|||                        |..|.:...|.|.|: .|..:...
Human   681 CPEVVEDGVADQTDEGG------------------------SVPVIISTSRVSAPAGGKASWGAD 721

  Fly   735 YSHW------CNEF------------EKYKSAMKQWQAKQEQCGLKDKTGPI 768
            .|:|      |..|            .:::::||.:..:.|...:..||.|:
Human   722 RSYWKEFLVMCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPV 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	149/500 (30%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	21/138 (15%)
SEMA4B	NP_001310963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910