DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and SEMA4D

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001358123.1	Gene:	SEMA4D / 10507	HGNCID:	10732	Length:	862	Species:	Homo sapiens

Alignment Length:	697	Identity:	208/697 - (29%)
Similarity:	318/697 - (45%)	Gaps:	129/697 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RLCSLSALLLVLVAQTVHVEYARADYEN-TWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLH 121
            |:|:....||:.:|.......|.|.... ||                  .|.:.|:..|....::
Human     2 RMCTPIRGLLMALAVMFGTAMAFAPIPRITW------------------EHREVHLVQFHEPDIY 48

  Fly   122 -YKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRN 185
             |....:.|..:.||:||.:.:|.:|..|||:...|....:.|...:   .|..|||.::.||.|
Human    49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKA---KCAEKGKSKQTECLN 110

  Fly   186 HIRVIQPMNFNGQKLYVCGTNAHNPK-DYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAV 249
            :|||:||:  :...||||||||..|. |::...:...|.:::.      |.|:||:|||.:.|:|
Human   111 YIRVLQPL--SATSLYVCGTNAFQPACDHLNLTSFKFLGKNED------GKGRCPFDPAHSYTSV 167

  Fly   250 YVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSF 314
            .|:.       .||:||:..|..::.:|.|:..::..         || :|....|::|:||.:.
Human   168 MVDG-------ELYSGTSYNFLGSEPIISRNSSHSPL---------RT-EYAIPWLNEPSFVFAD 215

  Fly   315 EI--------GE--FVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMN 369
            .|        ||  .|||||.|.:|||....:.:..|:|||||.|:||...:.:.|.::||||:.
Human   216 VIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280

  Fly   370 CSISSEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRDINAAFD-GKFKE 430
            || ..:....||.::.|:.:.:...|   |||.||...|.:..||||:|::......|. ||:.:
Human   281 CS-RPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344

  Fly   431 QAT---SNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNFIRKHPLMDKAVDHEF 483
            ..|   |::.|:. .|..||:||||.|         :..:..|||..|.|::.|||||.:|....
Human   345 STTVEQSHTKWVR-YNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPID 408

  Fly   484 GNPVFFKRDVILTKLVVDKIR-IDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEAS 547
            ..|...|:||..|::|||:.: :|  ...:.|.||:|..|.::|.:...|       .|.|.|.:
Human   409 NRPRLIKKDVNYTQIVVDRTQALD--GTVYDVMFVSTDRGALHKAISLEH-------AVHIIEET 464

  Fly   548 ---PHSEPIREMTLSHKTGS--LYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWDKDVNA 605
               ...||::.:.||.|.|:  :|..::..|.|..:|.|. ::.:|..||  .||||.|......
Human   465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCG-KHGTCEDCVLARDPYCAWSPPTAT 528

  Fly   606 C-------RPYQLGLLQDVANETSGICDTSVLRKKVTSSY-------GQTLHLSCFVK--MPEVL 654
            |       .|.: ||:|    |.||  |.||...|...||       |.|..|.|..|  :..|.
Human   529 CVALHQTESPSR-GLIQ----EMSG--DASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVF 586

  Fly   655 RKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY 701
            .|.|..           .::....||.......|::..::|||.|.|
Human   587 WKFQNG-----------VLKAESPKYGLMGRKNLLIFNLSEGDSGVY 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	156/492 (32%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	19/79 (24%)
SEMA4D	NP_001358123.1	Sema_4D	31..501	CDD:200520	161/526 (31%)
		PSI	503..554	CDD:214655	20/58 (34%)
		Ig_Sema4D_like	559..645	CDD:143281	18/75 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870