Protein Alignment Sema2b and SEMA4F

DIOPT Version :9

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_004254.2
• Gene: SEMA4F / 10505
• HGNCID: 10734
• Length: 770
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 174/603 - (28%)
• Similarity: 271/603 - (44%)
• Gaps: 81/603 - (13%)

  Fly    53 GKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSC 117
            |.|:........|||.:::..|.....|:....:..:.....|.|..:..|
Human    11 GPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPH-------------- 61

  Fly   118 GPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVE 182
             ..:|....:|..::.|||||.|.||.|:|....:.....|.::.|   :...||..|||:|. |
Human    62 -TYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPE---AHRQNCRKKGKKED-E 121

  Fly   183 CRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNST 247
            |.|.::::...  |...|..|||.|.:||..||:.:     |.|.|..:..|.||||::||..|.
Human   122 CHNFVQILAIA--NASHLLTCGTFAFDPKCGVIDVS-----RFQQVERLESGRGKCPFEPAQRSA 179

  Fly   248 AVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVG 312
            ||....       .|||.|...:...:.:|.|:      .||.| ::.||....| .|:.|.||.
Human   180 AVMAGG-------VLYAATVKNYLGTEPIITRA------VGRAE-DWIRTDTLPS-WLNAPAFVA 229

  Fly   313 SFEIG----------EFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKAR 367
            :..:.          :.:||||.|.:..:.:..:....||||||..|.||:..:.|.|.|:|||.
Human   230 AVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKAD 294

  Fly   368 MNCSISSEFPFYFNEIQSVY----KMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKF 428
            :.|. ..|.....:.:|.|.    ::......||..|::...|...||||::..:||....:|.|
Human   295 LLCP-GPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPF 358

  Fly   429 KEQATSNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNFIRKHPLMDKAVDHEFG 484
            :|.....:..|||:::.||:||||.|         ...:.:|||.||.|||.|||||:.|....|
Human   359 RELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADG 423

  Fly   485 NPVFFKRDVILTKLVVDKIRIDKLN-QEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASP 548
            :|:....|....::|..  |:..|: :|:.|.::.|..||:::.|:.   |.:.|.|.|: ...|
Human   424 HPLLVTTDTAYLRVVAH--RVTSLSGKEYDVLYLGTEDGHLHRAVRI---GAQLSVLEDL-ALFP 482

  Fly   549 HSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWDKDVNACRPY-- 609
            ..:|:..|.|.|..  |.|.:..:|.|::...|. |..||..|:  .||.|.|...::.|..:
Human   483 EPQPVENMKLYHSW--LLVGSRTEVTQVNTTNCG-RLQSCSECILAQDPVCAWSFRLDECVAHAG 544

  Fly   610 -QLGLLQDVAN-ETSGIC 625
             ..||:||:.: :.|.:|
Human   545 EHRGLVQDIESADVSSLC 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	148/482 (31%)
		Ig	632..720	CDD:299845
SEMA4F	NP_004254.2	Sema_4F	52..511	CDD:200522	151/508 (30%)
		PSI	512..563	CDD:279745	16/52 (31%)
		Ig_Sema4B_like	570..649	CDD:143280
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..725
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q9Z123	768..770

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910