DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and SEMA6C

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001171532.1	Gene:	SEMA6C / 10500	HGNCID:	10740	Length:	962	Species:	Homo sapiens

Alignment Length:	509	Identity:	167/509 - (32%)
Similarity:	263/509 - (51%)	Gaps:	79/509 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 NNALYVGAMDRIFRLNLRNISQSICERDVLI----LEPTGSDILNCVSKGKREKVECRNHIRVIQ 191
            |..|.|.|.|.:|..:|    |:..|.:.|:    |.....|:.||..:||... ||.|:|||:.
Human    70 NRTLLVAARDHVFSFDL----QAEEEGEGLVPNKYLTWRSQDVENCAVRGKLTD-ECYNYIRVLV 129

  Fly   192 PMNFNGQKLYVCGTNAHNP--KDYVINANLTHLPRSQYVPGIGL-GIGKCPYDPADNSTAVYVEN 253
            |  ::.|.|..||||:.:|  :.|    .:|.|.:.    |..| |..:||:|...::.|::.|.
Human   130 P--WDSQTLLACGTNSFSPVCRSY----GITSLQQE----GEELSGQARCPFDATQSNVAIFAEG 184

  Fly   254 GNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGE 318
                   :||:.|.|:|..:|:|::||      .|.:..  .|:.|||||.|.:|:||.:.|.|:
Human   185 -------SLYSATAADFQASDAVVYRS------LGPQPP--LRSAKYDSKWLREPHFVQALEHGD 234

  Fly   319 FVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGK-YMISQNWATYLKARMNCSISSEFPFYFNE 382
            .|||||||.:||....|:..:||||||||.|.||. ..:.::|.::||.|:|||:..:..|||:.
Human   235 HVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDV 299

  Fly   383 IQSVYKMPTD---DTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNS 444
            :|:: ..|.:   .:..:..|||.||.:.|||||::.:.:|...|:||||||.:.:.||.||...
Human   300 LQAL-TGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSED 363

  Fly   445 KVPEPRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVD 501
            :||.||||:|        .:.:..|||.||.||:.|||:|.||......|:.    .:.::.::.
Human   364 RVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLL----TLTSRALLT 424

  Fly   502 KIRIDKL---NQEFLVYFVATTSGHIYKIVQFMHYGQRHSN-----LVDIFEASP---------- 548
            ::.:|.:   :....|.|:.:..|.:.|:   :..|.|...     |.:|...||
Human   425 QVAVDGMAGPHSNITVMFLGSNDGTVLKV---LTPGGRSGGPEPILLEEIDAYSPARCSGKRTAQ 486

  Fly   549 HSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGW 599
            .:..|..:.|..:...|:||....:..:.::.|| |:.:|.| |::  ||||||
Human   487 TARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCA-RHGACQRSCLASQDPYCGW 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	155/484 (32%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845
SEMA6C	NP_001171532.1	Sema	53..517	CDD:301699	155/484 (32%)
SEMA6C	NP_001171532.1	PSI	518..570	CDD:279745	12/23 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910