DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and LOC100537452

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_003201673.4	Gene:	LOC100537452 / 100537452	-ID:	-	Length:	588	Species:	Danio rerio

Alignment Length:	665	Identity:	152/665 - (22%)
Similarity:	257/665 - (38%)	Gaps:	159/665 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 WNLYYEPPCCTGSSAAHH---LRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNL- 147
            |..|    .|  :|..||   :...||.:..|:....:.....:...:|..:|...:|::.::.
Zfish    13 WTSY----AC--ASKIHHNARVTVKKEGISRFAFENSNNSFIKLLSASNITWVVINERLYYIDTT 71

  Fly   148 -----RNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNA 207
                 :.::.::|..|           |.|.::           :.|:.. ..||..|::||| .
Zfish    72 QDFRPKPVNVNLCRND-----------LTCAAR-----------VSVLTE-GANGNLLFLCGT-T 112

  Fly   208 HNPKDYVINANLTHLPRSQYVPGIGLGIGKC----PYDPADNSTAVYVENGNPFGLPALYAGTNA 268
            ...|....:.|.|            ..:..|    .|.|..|.             |:|..|...
Zfish   113 DEEKTMCCSLNST------------FSLTNCFDFEHYKPDINE-------------PSLLVGDML 152

  Fly   269 EFTKADSVIFRSDLYNLTNGRKEAN-FKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYI 332
            .||.::..::|      .|..||.| :..:.:.:.|.|..  ..|..:..:.:|.||.|......
Zfish   153 YFTLSEKGLYR------INKNKERNIWPPSTQTEQKYLKL--IAGEGQHKDKMYSFFAEKHKNKE 209

  Fly   333 NCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKM-PTDDTK 395
            :.......||::.|.||:|| |..:..:|.:.:.||:.|....     |.::..|..: .|.|||
Zfish   210 DESDQWIPRVSQNCMNDKGGPKGQLQSSWTSMIYARLECGKRD-----FTQLIDVATIKTTHDTK 269

  Fly   396 FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTAT 460
            .||.|....|   .||||.|::.:|:..|:   ..|..:|:  :||.:      |||||..|:..
Zfish   270 IYALFRNYWN---MSAVCVYNMTEISTIFN---SSQFNANN--VPVSH------RPGTCVVDSTQ 320

  Fly   461 LPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIY 525
            |...||.|:::.|.|.:.|..|.| |:.|:..      ....|::|:: |:..|..::..||.::
Zfish   321 LNGEVLTFMKERPEMKQTVKPENG-PLIFRHH------HYSHIQVDRV-QDSTVLLLSLESGGVH 377

  Fly   526 KIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR 590
            |:::  ...|....::..:...||...|..|.|......||.::.:::.|||:|.|....:.|..
Zfish   378 KVLE--RPVQEPVFVIAEYLPFPHGSSIASMILHTSENLLYASSGNELIQIDLATCGVYGNECVE 440

  Fly   591 C--VSDPYCGWD-----------KDVNAC--RPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQ 640
            |  ..||||.||           :|.|.|  .||      |..:.|....:..|:..:.:|.|
Zfish   441 CRLSRDPYCKWDGLQCTIAEKTAQDTNNCDKPPY------DAPSRTITGANVPVISVQPSSKY-- 497

  Fly   641 TLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLL-AVNEGDGGRYDSY 704
                  |:..|.:.......|||..|.:          :...|:||.:.|: ::|:...|.|
Zfish   498 ------FLVCPVISHHATYHWYHSDTRE----------ECASTDEGCIYLIESMNKTHEGSY--- 543

  Fly   705 LDGTLLCSY---GVT 716
                 .|.|   |:|
Zfish   544 -----RCEYTENGIT 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	106/471 (23%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	19/89 (21%)
LOC100537452	XP_003201673.4	Sema	60..429	CDD:326631	104/454 (23%)
LOC100537452	XP_003201673.4	Ig_3	487..546	CDD:316449	16/84 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100