DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and sema4b

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_031755080.1	Gene:	sema4b / 100489037	XenbaseID:	XB-GENE-922109	Length:	850	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	194/757 - (25%)
Similarity:	329/757 - (43%)	Gaps:	163/757 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 GPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVE 182
            |..::.|..:.:..:||||||.:.:|.||..:.: |......:..:........|..|||..:.:
Frog    60 GVTYFTTLLLGKDGSALYVGAQEALFSLNSTDFT-SADYHSKIAWQADEEKKKECAFKGKDPQRD 123

  Fly   183 CRNHIRVIQPMNFNGQKLYVCGTNAHNP-------KDYVINAN-LTHLPRSQYVPGIGLGIGKCP 239
            |:|:|:::  :..|...||.|||.|.:|       .|:.:..| |.|       |.:..|..:||
Frog   124 CQNYIKIL--LQLNSTHLYTCGTFAFSPTCTYIKISDFSLEKNALGH-------PILEDGKVRCP 179

  Fly   240 YDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKL 304
            :||..||||:.|:.       .:||||.:.|...:.:|::|.           :.:.|:|.::.|
Frog   180 FDPEYNSTAIMVDG-------EMYAGTVSNFQGNEPIIYKSH-----------DSRITLKTENSL 226

  Fly   305 --LDKPNFVGSFEIGEF------------VYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYM 355
              |..|.||||..|.|.            :|:||.|...|:......:.||:|||||.|.||:.:
Frog   227 YWLQDPAFVGSAYIQESLPKGNPVGDDDKIYYFFSETGKEFDFFENTIVSRIARVCKGDLGGERV 291

  Fly   356 ISQNWATYLKARMNCSISSE-FPFYFNEIQSVYKM-PTDD----TKFYATFTT--NTNGLIGSAV 412
            :.:.|.::|||::.||...: ||  ||.::.::.: |.::    |.||..||:  |..|...|||
Frog   292 LQRRWTSFLKAQLICSCPGDGFP--FNVLKDMFVLTPGEEHWKSTIFYGVFTSQWNKGGAGSSAV 354

  Fly   413 CSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNF 468
            |::.:.::..||:|.|||.......|....|| |||||||.|         .|.:..:||.||||
Frog   355 CAFSMDEVQNAFNGLFKEVNRETQQWYTYTNS-VPEPRPGACITNSARDKKINSSLQMPDRVLNF 418

  Fly   469 IRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHY 533
            ::.|.|||.|:..:   |:..:..:...::.|.::|  .|.:.:.|.|:.|..|.::|.|..
Frog   419 VKDHFLMDSAIRSQ---PLLLQSQIRYQQISVQRVR--GLKKTYDVLFLGTDDGRLHKAVSV--- 475

  Fly   534 GQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPY 596
             .:..::::..:.....:|::|:.|....|.:|.::...|.|:.::.|: .|.||..|:  .|||
Frog   476 -NKMVHIIEEIKLFQDMQPVQELLLDPSKGLIYASSRSAVVQVPVSNCS-MYRSCGECILSRDPY 538

  Fly   597 CGWDK-----------------------DVNA---CRPYQLGLLQDVANET-----SGICDTSVL 630
            |.|:|                       |.|.   |:|         :|.|     :|..|.|..
Frog   539 CAWNKKGCHSVPHHTHDTKNQHWVQDIEDANTDAHCKP---------SNSTEAIGRAGKPDESEC 594

  Fly   631 RK-KVTSSYGQTLHLSCFVKMPEVLRKKQTR-WYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAV 693
            :: .:.|:...|  |.|     ::|....:| |.|:..|        ..:.|.....|.|:|  |
Frog   595 QEISMESNPANT--LPC-----KLLSNLASRVWLHNGKE--------IDSSYFVLPSGDLIL--V 642

  Fly   694 NEGDG-GRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQE 757
            :..|. |.|:.:                     |.::.::|:...:|...::...|....:.:.|
Frog   643 SSPDRVGTYECW---------------------SVEEGFRKLMVRYCVGTQEGIKATTTQRTETE 686

  Fly   758 QCGLKDKTGPISSNGKHVNDVFSNDALVXPRKYLYSFEFLSS 799
            :...|........|...|:...||.|.: .:.|...|..:|:
Frog   687 KVFSKISVIEKIVNASSVSSFPSNTAKLTGKSYWMEFVIMST 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	142/497 (29%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	17/90 (19%)
sema4b	XP_031755080.1	Sema	55..520	CDD:417757	143/499 (29%)
		PSI	521..564	CDD:214655	11/43 (26%)
		Ig	594..669	CDD:416386	19/112 (17%)
		Ig strand B	602..610	CDD:409353	3/14 (21%)
		Ig strand C	616..622	CDD:409353	2/5 (40%)
		Ig strand C'	624..627	CDD:409353	1/10 (10%)
		Ig strand D	631..635	CDD:409353	1/3 (33%)
		Ig strand E	637..643	CDD:409353	3/7 (43%)
		Ig strand F	649..658	CDD:409353	3/29 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100