DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema6b

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_002942249.3	Gene:	sema6b / 100487068	XenbaseID:	XB-GENE-6050017	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	191/599 - (31%)
Similarity:	293/599 - (48%)	Gaps:	92/599 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QAGSMCAT-----GKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHH 104
            |.|.:||.     |.|:.          |...:.|.:..|..:|..|:      |...|...:..
Frog     4 QTGLLCACLVLMGGLGES----------VFPEEAVPISKAGVEYLQTY------PVFLGKGPSKT 52

  Fly   105 LRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDI 169
            ....::.        |:.:...|  .|..||||..|.::::.|.:.|..:.....||.:....||
Frog    53 AERERDR--------LNIQKILM--VNRTLYVGDRDALYQIMLDSYSTELQYHKKLIWKSNHQDI 107

  Fly   170 LNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNP--KDYVINANLTHLPRSQYVPGIG 232
            ..|..|||:|. ||||.::|:...::  |.|::|||||.||  .||.|:.       .:.|....
Frog   108 NVCRMKGKQED-ECRNFVKVLLLKDY--QTLFICGTNAFNPVCADYSIDT-------LEQVGDTL 162

  Fly   233 LGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRT 297
            .|:.:|||||...:.|::.:.       .|:..|..:|...|:|::||      .|.:.|  .|:
Frog   163 SGMARCPYDPKHANVALFADG-------MLFTATVTDFLAIDAVLYRS------LGPRLA--LRS 212

  Fly   298 VKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWA 361
            ||:|||....|.||.:.|..|.|||||||.|:|:....|.|.||||||||||.|| :.::.:.::
Frog   213 VKHDSKWFKDPYFVHAVEWKEHVYFFFREVAMEFNYLEKVVVSRVARVCKNDMGGSQRVLEKQFS 277

  Fly   362 TYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTK--FYATFTTNTNGLIGSAVCSYDIRDINAAF 424
            ::||||:|||:..:..||||.||:|..:.....:  ..|.|:|.||.:.|||||.:|:..:.:.|
Frog   278 SFLKARLNCSVPGDSHFYFNVIQTVSNILNIGGRQVVLALFSTPTNSIPGSAVCVFDMEQVASVF 342

  Fly   425 DGKFKEQATSNSAWLPVLNSKVPEPRPGTC------HNDTATLPDSVLNFIRKHPLMDKAVDHEF 483
            .|:|:||.:.:|.|.||....||.||||.|      :|.:.:|||.||||::.||||:.:|....
Frog   343 SGRFREQRSPDSVWTPVPEELVPRPRPGCCVGHSHPYNSSRSLPDEVLNFVKSHPLMEDSVPSIG 407

  Fly   484 GNPVFFKRDVI---LTKLVVDKIRIDKLNQEFLVYFVATTSGHI--YKIVQFMHYGQ-----RHS 538
            |.| :..|.:.   ||.|.||  ....::....|.|:|:.||.:  |.::..|...:     ..:
Frog   408 GFP-WITRTLTRNQLTHLAVD--ASSGVHGNHTVLFLASDSGTVLKYLLIPKMSGSEIGTLANQT 469

  Fly   539 NLVDIFEASP--------HSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS- 593
            .|::..:..|        ..:.|..:.:...:|||.:|....:.::.:|.| :|:|.|.| |:.
Frog   470 VLLEELQTYPANRCGWDEEDQKILGIEVDKGSGSLLLAYSSCIVKVPLARC-QRHDGCIRSCLGT 533

  Fly   594 -DPYCGWDKDVNAC 606
             ||||.||...|.|
Frog   534 RDPYCAWDPANNLC 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	163/487 (33%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845
sema6b	XP_002942249.3	Sema	52..518	CDD:387663	163/503 (32%)
sema6b	XP_002942249.3	PSI	519..>548	CDD:214655	14/30 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010