Protein Alignment Sema2b and sema6c

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: XP_002937315.2
• Gene: sema6c / 100486277
• XenbaseID: XB-GENE-989787
• Length: 1043
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 197/622 - (31%)
• Similarity: 293/622 - (47%)
• Gaps: 133/622 - (21%)

  Fly   131 NNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNF 195
            |..|:|.|.|.::.::||...::|.. |..:...| .|:.||..:||. :.||.|:|:|:.|.
 Frog    67 NQTLFVAARDHVYAIDLRRAKEAIIP-DKYVTWKT-QDMENCAMRGKL-RDECYNYIKVLVPK-- 126

  Fly   196 NGQKLYVCGTNAHNP--KDYVINA--------NLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVY 250
            |.|.|..||||:.||  :.|.|..        |               |..:||:|....:.|::
 Frog   127 NDQTLVACGTNSFNPMCRSYKIKTLEQEGEEFN---------------GQARCPFDAKQANVALF 176

  Fly   251 VENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFE 315
            .: ||      ||:.|.|:|..:|:||:||      .|.| :...||||||||.|.:|:|:.:.|
 Frog   177 AD-GN------LYSATMADFQASDAVIYRS------LGEK-SPVLRTVKYDSKWLREPHFIHAVE 227

  Fly   316 IGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGK-YMISQNWATYLKARMNCSISSEFPFY 379
            .|.:|||||||.::||...||..:|||.||||||.||. .::.:.|.::||||:|||:..:..||
 Frog   228 YGNYVYFFFREISMEYTTIGKVTFSRVGRVCKNDMGGSPRVLEKYWTSFLKARLNCSVPGDSFFY 292

  Fly   380 FNEIQSVYKMPTDDTK--FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVL 442
            |:.:|||..:.|.:.:  ....|.|..|.:.||.||:|.:.||...|:||||||.|:.|||.|:.
 Frog   293 FDVLQSVSDILTINNRPAVIGVFGTQANSITGSGVCAYYMDDIEKVFNGKFKEQKTTESAWTPIP 357

  Fly   443 NSKVPEPRPGTC--HNDTAT------LPDSVLNFIRKHPLMDKAVDHEFGNPVF------FKRDV 493
            ..|||.||||.|  :...||      .||..|:||:.:||:|:||......|.|      ||
 Frog   358 EDKVPTPRPGCCAGYGKAATYKTSNEFPDETLSFIKSYPLLDEAVLSITETPWFTKTTSRFK--- 419

  Fly   494 ILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLV------DIFEASP---- 548
             ||.|..|.......|  :.|.|:.:..|.:.|::.    |...::.|      ||...:|
 Frog   420 -LTHLAADTSAGPYGN--YTVLFLGSEDGKVLKVLS----GTTENSTVETLLLEDINVYNPAKCN 477

  Fly   549 ---HSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGWDKDVNACR 607
               ....|..:.|..:..:|:||....:.::.::.| ..|.:|.| |::  ||||.|.|. .||.
 Frog   478 VKKEDRRILGLQLDRENHALFVAFSSCIIRVPLSRC-ELYGTCRRSCLASRDPYCVWLKS-GACA 540

  Fly   608 PYQLGLLQDVANETSGICDTSVLRKK--------VTSS----------YGQT-----LHLSCFVK 649
            .|:        |:..|..:..:.:.|        ||||          ||:.     :.::....
 Frog   541 SYR--------NDIRGSFEQDIEQSKNWGNCQDVVTSSGSVGNEGDSAYGKAPPSGDIAIASVAS 597

  Fly   650 MPEVLR-------------KKQTRWYHHSTEKGRYEV 673
            :..|.|             .:.:.|:...|:..|.||
 Frog   598 LGHVTRLGYSPPGVTSDGYYQLSAWHTLKTQGVRQEV 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	167/487 (34%)
		PSI	583..>606	CDD:396154	10/25 (40%)
		Ig	632..724	CDD:472250	14/78 (18%)
		Ig strand B	642..646	CDD:409353	0/3 (0%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353
		Ig strand F	700..705	CDD:409353
		Ig strand G	717..720	CDD:409353
sema6c	XP_002937315.2	Sema_6E	50..511	CDD:200531	167/487 (34%)
		PSI	512..563	CDD:396154	17/60 (28%)