DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema4g

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_002938767.1	Gene:	sema4g / 100038182	XenbaseID:	XB-GENE-856594	Length:	830	Species:	Xenopus tropicalis

Alignment Length:	656	Identity:	195/656 - (29%)
Similarity:	295/656 - (44%)	Gaps:	117/656 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 FSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKRE 179
            ||....:|.|..:::....|||||...||.||..||||..  :..:..|.|......|:.|||..
Frog    49 FSSRVSNYSTLLLEDERGILYVGARGAIFSLNSTNISQRY--QKAIPWEVTAQKHDECIKKGKNN 111

  Fly   180 KVECRNHIRVIQPMNFNGQKLYVCGTNAHNP-------KDYVINANLTHLPRSQYVPGIGLGIGK 237
            :.||.||||::  :.||...||||||.|.:|       :.:|:::....            |..|
Frog   112 QTECFNHIRLL--LRFNETHLYVCGTYAFSPLCSFIDSRTFVLSSETEE------------GKEK 162

  Fly   238 CPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDS 302
            ||||||.....:.|:.|       ||..:..||.....:  |.:|...:...:|:|.
Frog   163 CPYDPAKGYVGLLVDGG-------LYTASLYEFRNLPDI--RRNLLQRSLKTEESNL-------- 210

  Fly   303 KLLDKPNFVG--------SFEIG--EFVYFFFREHAVEYINC--GKAVYSRVARVCKNDRGGKYM 355
            ..|:.|.||.        :.|:|  :.:|:||.|..||..:.  |....| ||||||:|.|||.:
Frog   211 HWLNDPEFVSAALVQESMNVEVGDDDKIYYFFNEKVVEENSAFLGSKTAS-VARVCKDDMGGKKI 274

  Fly   356 ISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPT---DDTKFYATFTTNTNGLIGSAVCSYDI 417
            :.:.|.::||||:.|.:    ||| ..::|.|.:..   |.|.||..|......:..||:|.|.|
Frog   275 LQKKWTSFLKARLVCYM----PFY-EVLKSAYTLELGSWDTTIFYGAFILQWKNMEESAICRYSI 334

  Fly   418 RDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC---------HNDTATLPDSVLNFIRKHP 473
            .||...|:|.:.|...|:..| .....:||.||||:|         .|.:..||::||:|::.||
Frog   335 SDIQKVFEGPYMEYQYSSRKW-SRYEGEVPSPRPGSCITNEFRMNGFNTSQDLPNNVLDFVKLHP 398

  Fly   474 LMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFL-VYFVATTSGHIYKIV---QFMHYG 534
            ||.:.|......|:..|:::|.|::.||  |:..||.|:. |.|:.|..|.|:|.|   ..:|
Frog   399 LMYEKVRPVGEQPLLVKKNIIYTRIAVD--RVKALNDEYYDVLFLGTDDGWIHKAVVIGSMVH-- 459

  Fly   535 QRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYC 597
                 :::..:.....:|:..:.:|.|..:||:.....|.||.:..|: :|.||:.|:  .:|||
Frog   460 -----IIEEIQVYKFPQPVENLVISKKQNALYIGAQSGVLQIPLFGCS-QYTSCYDCILARNPYC 518

  Fly   598 GWDKDVNACRPY-----QLGLLQDVANETSGIC----DTSVLRKKVTSSY-GQTLHLSCFVKMPE 652
            .||.  :|||..     :..:.||:.|...| |    |...|:|:|.... |..:.|.|
Frog   519 AWDG--HACRDIIGAKNRTQMTQDMQNGNGG-CLNSTDDGALKKRVRRVLKGNDVLLQC------ 574

  Fly   653 VLRKKQTR--WYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLD----GTLLC 711
            .||....|  ||.:.|:|     .|....:......||::........|.|..|.:    .:|:.
Frog   575 ELRSNLARPQWYVNGTDK-----LYDSEGHTRLGVDGLLITDTLPEHSGEYSCYSEENGLQSLVA 634

  Fly   712 SYGVTV 717
            .|.:.|
Frog   635 VYSLNV 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	152/493 (31%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	21/93 (23%)
sema4g	XP_002938767.1	Sema	47..499	CDD:417757	154/498 (31%)
		PSI	500..>527	CDD:214655	12/29 (41%)
		Ig_Sema4B_like	557..643	CDD:409456	22/95 (23%)
		Ig strand B	570..574	CDD:409456	1/3 (33%)
		Ig strand C	582..586	CDD:409456	1/3 (33%)
		Ig strand E	605..609	CDD:409456	2/3 (67%)
		Ig strand F	619..624	CDD:409456	1/4 (25%)
		Ig strand G	636..639	CDD:409456	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010