DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and CTS2

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_010659.1	Gene:	CTS2 / 851977	SGDID:	S000002779	Length:	511	Species:	Saccharomyces cerevisiae

Alignment Length:	418	Identity:	100/418 - (23%)
Similarity:	158/418 - (37%)	Gaps:	123/418 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GSYY-----YKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRITDKILLLEKDKLSSVKTMK 91
            |.||     ||.|.. |...::.:..:|:.. :...::..:|.:..||....||.:...|:....
Yeast    76 GVYYSNWSPYKPRFH-FPHDINLKQVSHIYY-AFFKINSRTGGIENTDSWSDLEMNLYKSLAIKN 138

  Fly    92 WDSIK-------------------------------KVMFTIGGWEEDSSSFSRMVASPKKRDNF 125
            .:.||                               ||:.:|||| .||.:|..::...|...||
Yeast   139 SELIKESSNNSVQNILPLGCIGELFYLKNTCSDKKFKVIMSIGGW-SDSENFKIIIKDDKLLQNF 202

  Fly   126 YSSMLEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEELGL--------IFRK---NQLIL 179
            ..|.:|.|||.||||:.:||.:|   |.:..:.:.::.|:..|.|        ||.|   :...|
Yeast   203 VDSSVETMFRLGFDGIDLDWEFP---GNNESEPRGYLKLVRMLRLKLNSLESQIFGKRTEDHFQL 264

  Fly   180 MVAVLGRRDNRILESYNIPEIVNHSDFIHLMMHD------EQDPYHLRLAYNAPLVGYEGSVTDS 238
            .:|....:|.  |....|.||..:.|:.::|.:|      |...||..|.....|.|      :.
Yeast   265 SIAAPAFKDK--LFYLPITEIDQYVDYWNMMTYDYYGSWSETTGYHSNLFSETELNG------NF 321

  Fly   239 IMHW--KRNGGAPEKLILGIPLFVRSFTMDR------NQSTV--GSACKGPGRQTKQ----SHRP 289
            .||:  .|.|....||:||:..:.|||.:..      ||:||  ....||.|:.||:    ..:.
Yeast   322 AMHYMIDRFGVNSRKLVLGMAAYGRSFHIKDNKFEPFNQNTVLINKIFKGVGKPTKEIDKADGKE 386

  Fly   290 GFMTY-----------------NEWCVQQSKWSRMFDQLAKVPYATRGDQWVSYENPRSIWAKMH 337
            |...|                 :.:|         ||:        :...::||:|.:|:..|..
Yeast   387 GIWPYKNLPKIGTIEQYDPKYVSAYC---------FDE--------KNSIFISYDNTKSVKTKAE 434

  Fly   338 LLQEHKLGGAMAWTIDVDDFRGRCGEQH 365
            .:..:.|||...|.        .|||.:
Yeast   435 YVTHNNLGGGFWWE--------SCGEAY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	100/418 (24%)
		Glyco_hydro_18	47..355	CDD:279094	90/386 (23%)
		ChtBD2	394..438	CDD:214696
CTS2	NP_010659.1	ChiA	36..474	CDD:225862	100/418 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I1336
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		otm46727
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
TreeFam	1	0.960	-	-
	7	6.820