DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and chia.3

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_998378.1	Gene:	chia.3 / 406819	ZFINID:	ZDB-GENE-040426-2891	Length:	471	Species:	Danio rerio

Alignment Length:	477	Identity:	136/477 - (28%)
Similarity:	216/477 - (45%)	Gaps:	71/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LICG-----C-IAKEYNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRI 72
            ||.|     | :|....:.|.:...|.|..|..::...::|..|||||:.  ...:.....|| :
Zfish     6 LIAGLSLVLCHVAFSMEMACYFTNWSQYRPGIGKYTPANVDPYLCTHLIY--AFSIINQRNEL-V 67

  Fly    73 T----DKILLLE----KDKLSSVKTMKWDSIKKVMFTIGGWEEDSSSFSRMVASPKKRDNFYSSM 129
            |    |:.|...    |:|..::||         :..:|||...|:.||.||::|..|..|..|.
Zfish    68 TYEWNDETLYKAFNELKNKNPTLKT---------LLAVGGWNFGSAQFSIMVSNPANRKTFIQST 123

  Fly   130 LEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEELGLIFRK------NQLILMVAVLGRRD 188
            ::|:...||||:.:||.||...|..|:|:|.|.:|.:||...:..      |..:::.|.:....
Zfish   124 IKFLRTHGFDGLDLDWEYPGARGSPPEDKQRFTLLCKELVAAYEAESKATGNPQLMLTAAVSAGK 188

  Fly   189 NRILESYNIPEIVNHSDFIHLMMHDEQDPYHLRLAYNAPLVGYEGSV---------TDSIM-HWK 243
            ..|.:.|.|.||..:.:||::|.:|....:.....:|:||  |:||.         ||..| :|:
Zfish   189 GTIDDGYEIAEIAKYLNFINVMTYDFHGTWERFTGHNSPL--YQGSKDEGDLIYFNTDYAMRYWR 251

  Fly   244 RNGGAPEKLILGIPLFVRSFTMDRNQSTVGSACKGPGRQTKQSHRPGFMTYNEWC--VQQSKWSR 306
            .||...|||.:|...:.|:|.:..:.::||:...||......:...||.:|.|.|  ::.:....
Zfish   252 DNGTPVEKLRMGFAAYGRTFRLTSSDTSVGAPASGPASAGTYTREAGFWSYYEICGFLEGTTIQW 316

  Fly   307 MFDQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRGR-CGE-QHGLLR 369
            :.||  ||||||:..:||.::...|...|:..|::...|||..|.:|:|||.|: |.: .|.|:.
Zfish   317 IDDQ--KVPYATKNSEWVGFDTKESYETKVRYLKDKNFGGAFVWALDLDDFAGQFCSQGNHPLMA 379

  Fly   370 VIFSALG-----------DKNGLTTEKPTTEAS--------GLC--PHDGFSRDGWDCRLYHECR 413
            .:.:.|.           .|.|.:|.:|||..:        |.|  ..||......|...|:.|.
Zfish   380 HLRNLLDIELPPMPSTTTPKPGQSTTRPTTTTTTTTHAPGPGFCNGKPDGLYAHPNDPNKYYSCA 444

  Fly   414 DGERIYYECLEGQYFDENQIVC 435
            .|.....:|..|..||::...|
Zfish   445 GGHTFVEKCAVGTVFDDSCKCC 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	111/377 (29%)
		Glyco_hydro_18	47..355	CDD:279094	100/333 (30%)
		ChtBD2	394..438	CDD:214696	12/44 (27%)
chia.3	NP_998378.1	Glyco_18	24..363	CDD:214753	104/354 (29%)
		GH18_chitolectin_chitotriosidase	25..385	CDD:119351	111/375 (30%)
		ChtBD2	421..469	CDD:214696	13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820