DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and Cht7

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	129/451 - (28%)
Similarity:	219/451 - (48%)	Gaps:	54/451 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRITDKILLLEKDKLSSVKT 89
            |||.....|....|..:|...::|.:||||:|.......|....|  .||.    :.:...||..
  Fly   560 VFCYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFATLQDYKLTE--ATDD----DPENYESVIA 618

  Fly    90 MKWDSIK-KVMFTIGGWEEDSSSFSRMVASPKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLLGG 153
            ::.::.. :::..||||...|:.|..:.::..:.:.|....::|:..:.|:|:.:||.||.
  Fly   619 LRDNNPDLQILLAIGGWAFGSTPFKELTSNVFRMNQFVYEAIDFLRDYKFNGLDVDWEYPR---- 679

  Fly   154 HPDDRQNFVILLEELGLIF----RKNQL--ILMVAVLGRRDNRILESYNIPEIVNHSDFIHLMMH 212
            ..:||..:|.||:||.:.|    :.:.|  :|:.|.:......|...|::|||..:.|||::|.:
  Fly   680 GAEDRVAYVSLLKELRVAFEGEAKSSGLPRLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTY 744

  Fly   213 DEQDPYHLRLAYNAPL------VGYEGSVT--DSIMHWKRNGGAPEKLILGIPLFVRSFTM-DRN 268
            |....:...:.:|:||      .||:..:|  .|...|.:.|...|||::|:|.:.|||.: :..
  Fly   745 DFHGQWERTVGHNSPLFALESATGYQKKLTVDYSAREWVKQGAPKEKLLIGMPTYGRSFELVNDT 809

  Fly   269 QSTVGSACKGPGRQTKQSHRPGFMTYNEWC--VQQSKWSRMFDQLAKVPYATRGDQWVSYENPRS 331
            |..:||...|.|:..|.::..||::|.|.|  :.....:.::|...:||:|.||:|||.:::.||
  Fly   810 QFDIGSPSSGGGKAGKFTNEAGFLSYYEVCSFLAADNTTLVWDSEQQVPFAYRGNQWVGFDDERS 874

  Fly   332 IWAKMHLLQEHKLGGAMAWTIDVDDFRGRCGE-QHGLLRVI----------------FSALGDKN 379
            :..|...|:|...||.|.|:||:|||.||||. ::.||..:                :.:.|.:.
  Fly   875 LKTKTEWLKEQGFGGIMVWSIDMDDFSGRCGSGKYPLLTALNDELKDYKVELEYDGPYESHGPRG 939

  Fly   380 GLTTEKP----TTEASGLCPHDGFSRDGWDCRLYHECRDGERIYY-ECLEGQYFDENQIVC 435
            ..||:.|    ..|..|   |..:.:|..||..|:.| :|||.:: .|.....|:..:.||
  Fly   940 AYTTKDPHDVTCAEEDG---HISYHKDWADCTHYYMC-EGERKHHMPCPANLVFNPQENVC 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	110/384 (29%)
		Glyco_hydro_18	47..355	CDD:279094	95/325 (29%)
		ChtBD2	394..438	CDD:214696	13/43 (30%)
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351
		Glyco_18	559..898	CDD:214753	101/347 (29%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	110/368 (30%)
		CBM_14	951..1005	CDD:279884	15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		otm46727
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
	8	7.850