DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and Cht10

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	129/427 - (30%)
Similarity:	209/427 - (48%)	Gaps:	50/427 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRITDKILLLEKDKLSSV 87
            |.|.|.:...::|.||..:|....:::.||||::.|..: :|.....||..|....:|.:..:.|
  Fly   965 YKVICYFTNWAWYRKGIGRFTPDDINTELCTHVIYGFAV-LDYSELVLRTHDSWADVENNFYTRV 1028

  Fly    88 KTMKWDSIKKVMFTIGGW-EEDSSSFSRMVASPKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLL 151
            .::|...| ||...:||| :.....:||:|.||..|..|....|||:.::||:|:.:||.||...
  Fly  1029 TSLKSKGI-KVSLALGGWNDSQGDKYSRLVRSPMARSRFVRHALEFIEKYGFEGLDLDWEYPVCW 1092

  Fly   152 -----GGHPDDRQNFVILLEELGLIFRKNQLILMVAVLGRRDNRILES-YNIPEIVNHSDFIHLM 210
                 .|..:::..|...::||...||...|:|..||...|  :|::: |:||::..:.|:|.:|
  Fly  1093 QTECNKGSTEEKDGFTAWVQELSEAFRPRGLMLSTAVSPSR--KIIDAGYDIPQLSRYFDWIAVM 1155

  Fly   211 MHDEQDPYHLRLAYNAPLVGYEG------SVTDSIMHWKRNGGAPEKLILGIPLFVRSFTMDR-N 268
            .:|....:..:..:.|||..:..      :|..||.:|...|...:||::||||:.:|||::. |
  Fly  1156 TYDFHGHWDKKTGHVAPLYHHPDDDFEYFNVNYSINYWMEKGAPSQKLVMGIPLYGQSFTLENTN 1220

  Fly   269 QSTVGSACKGPGRQTKQSHRPGFMTYNEWC--VQQSKWSRMFDQLAKV-PYATRGDQWVSYENPR 330
            .|.:.:....||...:.:...||:.|.|.|  |.:..|..:.|:..:: |||.:|.|||||::|.
  Fly  1221 SSGLNAKAPAPGEAGEFTRAAGFLAYYEICERVNRQGWQVVHDEFGRMGPYAYKGTQWVSYDSPD 1285

  Fly   331 SIWAKMHLLQEHKLGGAMAWTIDVDDFRGRCGE-QHGLLRVIFSALGDKNGL-----TTEKPTTE 389
            .:..|..|::..||||.|.|.:|:|||:.|||. .|.||..|.:.|.|...|     ..|...||
  Fly  1286 MVRKKSLLVRSLKLGGGMVWALDLDDFKNRCGNGVHPLLTEIHNVLKDPPSLMEIPGPIETTPTE 1350

  Fly   390 ASGL-----------------------CPHDGFSRDG 403
            ..|:                       |.::|...:|
  Fly  1351 YPGMEEEIHESNGEGPEVQPIEAVMQTCENEGEEHEG 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	118/367 (32%)
		Glyco_hydro_18	47..355	CDD:279094	102/324 (31%)
		ChtBD2	394..438	CDD:214696	3/10 (30%)
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696
		CBM_14	801..848	CDD:279884
		CBM_14	875..918	CDD:279884
		Glyco_18	966..1310	CDD:214753	108/347 (31%)
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351	118/367 (32%)
		Glyco_18	1410..1753	CDD:214753
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351
		ChtBD2	1834..1871	CDD:214696
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46727
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850