DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and Chil6

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_017175043.1	Gene:	Chil6 / 229688	MGIID:	2682303	Length:	452	Species:	Mus musculus

Alignment Length:	400	Identity:	114/400 - (28%)
Similarity:	193/400 - (48%)	Gaps:	51/400 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TSFQYVFMIMIFLICGC-IAKEYNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLG-SGIGVD 64
            |..:.||::.:.|:... :...|.:.|.::....:...........:|..|||||:.. :||.
Mouse    17 TISKLVFIMGLNLLLNAQMGSAYQLMCYFNNWPQHQPDVRDIKHEDIDPCLCTHLIYSFAGIW-- 79

  Fly    65 GDSGELRITDKILLLEKDKLSSVKTMK-----WDSIK--------KVMFTIGGWEEDSSSFSRMV 116
              .....:|.:   .|.|.......:|     |..|.        |.:.:||.|.....||..||
Mouse    80 --ENNFTMTKR---KELDDYKGFNDLKKRQHLWRFIHASFRNNKLKTLLSIGCWNFGDGSFITMV 139

  Fly   117 ASPKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEELGLIF-------RK 174
            ::|:.|.:|.:|:::|:.::||||:.:.|:||...|..|.|:..|.||:.|:...|       :|
Mouse   140 STPENRHSFITSIIKFLRKYGFDGLNLAWQYPGCYGSPPRDKHLFTILMHEIRKAFEKEVSKNKK 204

  Fly   175 NQLILMVAVLGRRDNRILESYNIPEIVNHSDFIHLMMHDEQDPYHLRLAYNAPLVGYEGSVTDSI 239
            .:|::..||.| ..:.|...|.||::....|:|.:|.:|....:......|:||  |:..:...:
Mouse   205 PRLMVTAAVAG-VISTIQFGYEIPQLSQSLDYIQVMTYDLHGSWDGYTGENSPL--YKSPIETGV 266

  Fly   240 M----------HWKRNGGAPEKLILGIPLFVRSFTM-DRNQSTVGS-ACKG--PGRQTKQSHRPG 290
            .          :||:.|.:|||||:|.|.:..:|.: |..::.:|: :.:|  ||..|||:   |
Mouse   267 KAFHNIKYIMDNWKKKGASPEKLIVGFPAYGHTFILSDSTKTEIGAPSNRGGHPGPHTKQT---G 328

  Fly   291 FMTYNEWCVQQSKWS-RMFDQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDV 354
            |..|.|.|......: ::::...:||||..|::||.|:|.:|...|...|:.:..||||.||||:
Mouse   329 FWAYYEICTFLKNGAIQVWNAAQQVPYAFHGNEWVGYDNIKSFHIKAQWLKRNNYGGAMIWTIDM 393

  Fly   355 DDFRGR-CGE 363
            ||:.|. ||:
Mouse   394 DDYTGSFCGQ 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	109/375 (29%)
		Glyco_hydro_18	47..355	CDD:279094	103/343 (30%)
		ChtBD2	394..438	CDD:214696
Chil6	XP_017175043.1	GH18_chitolectin_chitotriosidase	41..416	CDD:119351	109/375 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920