DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and Chil5

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001074285.1	Gene:	Chil5 / 229687	MGIID:	2676649	Length:	431	Species:	Mus musculus

Alignment Length:	411	Identity:	116/411 - (28%)
Similarity:	197/411 - (47%)	Gaps:	68/411 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MIMIFLICGC-------IAKEYNVFCQYD--------LGSYYYKGRSQFFEWHLDSRLCTHLVLG 58
            |..:.|:.|.       :...|.:.|.|:        |||        |....:|..|||||:..
Mouse     1 MTKLILVTGLALLLNPQLGSAYQLMCYYNNVAQNRPKLGS--------FNPADIDPCLCTHLIYA 57

  Fly    59 SGIGVDGDSGELR----ITDKILLLEKDKLSSVKTMKWDSIK-KVMFTIGGWEEDSSSFSRMVAS 118
            .. |:..:...:|    :||         ..::.|:|..::: |.:..|||.:...:.||.||::
Mouse    58 FA-GMQNNKVTMRSMNDLTD---------YQALNTLKSRNVQLKTLLAIGGRDFGPAPFSAMVST 112

  Fly   119 PKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLE------ELGLIFRKNQL 177
            |..:..|.:|.::|:.::||||:.:||::|...|....|:..|.:|::      ||..|..|:..
Mouse   113 PHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQKIREAFELEAIENKSPR 177

  Fly   178 ILMVAVLGRRDNRILESYNIPEIVNHSDFIHLM---MHDEQDPYHLRLAYNAPLVGYEGSVTDS- 238
            :::.|.:....:.|...|.||::.:..|:|.:|   :|..||.|   ...|:||  |: |:.|:
Mouse   178 LMVTATVAGVISTIQSGYEIPQLSHFLDYIQVMTYNLHGSQDGY---TGENSPL--YK-SLNDTG 236

  Fly   239 ----------IMHWKRNGGAPEKLILGIPLFVRSFTM-DRNQSTVGSACKGPGRQTKQSHRPGFM 292
                      :.:|..||.||||||:|.|.:.::||: |.:.:.:.:.....|.....:...|..
Mouse   237 INTLLNVDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTW 301

  Fly   293 TYNEWC-VQQSKWSRMFDQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDD 356
            .|.|.| ......:..:|...:||||.:|::||.|:|.:|...|...|:::.|||||.||:|:||
Mouse   302 AYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDD 366

  Fly   357 FRGR-CGE-QHGLLRVIFSAL 375
            |.|. |.: |..|...:.:||
Mouse   367 FTGSFCNQGQFPLTSTLKNAL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	110/386 (28%)
		Glyco_hydro_18	47..355	CDD:279094	97/334 (29%)
		ChtBD2	394..438	CDD:214696
Chil5	NP_001074285.1	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	110/386 (28%)
Chil5	NP_001074285.1	Glyco_18	26..365	CDD:214753	103/362 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020