DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht12 and lmd-5

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001309512.1	Gene:	lmd-5 / 187942	WormBaseID:	WBGene00020141	Length:	1518	Species:	Caenorhabditis elegans

Alignment Length:	442	Identity:	114/442 - (25%)
Similarity:	183/442 - (41%)	Gaps:	86/442 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GDSGELRITDKILLLEKDKLSSVKTMKWDSIKKVMFTIGGWEEDSSSFSRMVASPKKRDNFYSSM 129
            |...|.|..|.     |.|..:|     :|..:|:|.:||| ::|..||.:.|...||.||..|:
Worm  1043 GKKAERRFVDM-----KKKARAV-----NSGVRVLFAVGGW-DNSQYFSSVAADSGKRRNFVDSV 1096

  Fly   130 LEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEEL-----GLIFRKNQ----LILMVAVLG 185
            ..|:.....|||.:||.||.:.||   |:||.|.|:.||     |:..|.|:    ||.:.:..|
Worm  1097 ASFIEHHKIDGVDLDWEYPEMKGG---DKQNHVTLIRELRERFNGMASRNNRKDPYLITLASAAG 1158

  Fly   186 RRDNRILESYNIPEIVNHSDFIHLMMHDEQDPYHLRL-AYN---APLV-----GYEGSVTD--SI 239
            ..:.|  |.|::..|:|::|||::|.:|....:..:. ||.   |||.     |:.|.:..  |:
Worm  1159 EWNLR--EGYDLKGILNYADFINVMTYDYYGAWESKWGAYTGTPAPLYFGSLKGFSGKLNADFSM 1221

  Fly   240 MHWKRNGGAPEKLILGIPLFVRSF-----TMDRNQSTVGSACKGPGRQTKQSHRPGFMTYNE--- 296
            ..:..|...|.:|.:|:|.:.|.:     .:|.:.:...:|....|:     :..|::.:..
Worm  1222 KFYACNTKKPSQLTMGVPFYGRYWKNVLEPIDASDNMWRTAAPQNGK-----YEGGYVGWRNLEK 1281

  Fly   297 --WCVQQSKWSRMFDQLAKVPYATRGD--QWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDDF 357
              |    :|.|..:.:..|.||.....  .::.:||.||:..||.......|||.|.|.:|:||
Worm  1282 EGW----NKGSATWHKKTKTPYIMNNGARMFLGFENERSLKEKMDYATNRNLGGLMIWALDLDD- 1341

  Fly   358 RGRCGEQHGLLRVIFSA------LGDK-----------NGLTTEKPTTEASGLCPHDGFSRDGWD 405
                 :...||.::.||      .|||           ...|.|.......|.|.......:|:
Worm  1342 -----DADTLLNLVSSAGLCSGGSGDKITYKCVPIDDVRWWTPENSDENRQGQCGKSAPLINGF- 1400

  Fly   406 CRLYHECRDGERIYYECLEGQY--FDENQIVCRPAAEVKCDQNFVIWRPGMP 455
               |..|...:..:..|....|  .:|....|:.....:.|.:.::..|..|
Worm  1401 ---YPVCDPDDPGFSCCGAAGYCGSEEEYCECKGCVNYRKDPDLIVKEPVKP 1449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	97/347 (28%)
		Glyco_hydro_18	47..355	CDD:279094	91/321 (28%)
		ChtBD2	394..438	CDD:214696	8/45 (18%)
lmd-5	NP_001309512.1	LysM	22..65	CDD:197609
		LysM	77..120	CDD:197609
		LysM	151..194	CDD:197609
		LysM	220..260	CDD:197609
		LysM	275..312	CDD:197609
		LysM	386..429	CDD:197609
		Self-incomp_S1	851..944	CDD:283566
		Glyco_18	991..1336	CDD:214753	89/317 (28%)
		GH18_chitinase-like	992..1336	CDD:299167	89/317 (28%)
		ChtBD1_GH18_2	1388..1435	CDD:211315	9/50 (18%)
		ChtBD1_GH18_2	1462..1513	CDD:211315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750