DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and chil-18

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_496024.2	Gene:	chil-18 / 187735	WormBaseID:	WBGene00011161	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	93/385 - (24%)
Similarity:	167/385 - (43%)	Gaps:	54/385 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CQYDLGSYY--YKG----RSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRITDKILLLEKDKLS 85
            |:..:..||  ::|    |||..:       .||.|. :.|.:|.: |:|:....    :|::..
Worm    67 CKKRVVGYYSEWEGTEITRSQLGK-------LTHAVF-AFIHMDSE-GKLQFKTN----QKERFE 118

  Fly    86 SVKT--MKWDSIKKVMFTIGGWEEDSSSFSRMVASPKKRDNFYSSMLEFMFRWGFDGVQIDWRYP 148
            .:||  ...:|..|||.:||| :.:|.:|..:::..:|:..|..|:..|:.:....||.|.|::
Worm   119 KLKTAVKNANSDTKVMISIGG-DHNSENFGSVLSDSEKKSMFIDSIARFIRQHKIHGVDIYWKW- 181

  Fly   149 TLLGGHPDDRQNFVILLEELG---LIFRKNQLILMVAVLGRRDNRILESYNIPEIVNHSDFIHLM 210
              ||....:..:|...|::|.   ...|.:.:|.:||...:.|.| .:.|...:.:.:.||:::.
Worm   182 --LGNSETEHHDFPSFLKDLKEKLKTVRDDSIISIVAPQAKMDRR-HDGYKFDDFMEYIDFVNVF 243

  Fly   211 MHDEQDPYHLR----LAYNAPLVGYEG-----SVTDSIMHWKRNGGAPEKLILGIPLFVRSFTMD 266
            ..|...|:..:    ...:|||.|..|     :|..::.::......|.|..:.||.:||.:...
Worm   244 SMDYYGPWPNQWGTPTGPSAPLYGGIGVKKHFNVDSTMKYYTCMTEDPSKFNMVIPFYVRLWKNV 308

  Fly   267 RNQSTVGSACKGPGRQTKQSHRPGFMTYNEWCVQQSKWS---RMFDQLAKVPYATRGD--QWVSY 326
            :...:.|:...... ..|.....|....:.|.|....|.   .::|.:.|.||....:  .::::
Worm   309 KEPISSGTEVFRRA-DLKNGAAVGNSYMSRWTVDHEGWELTPALWDDVTKTPYVWNQETGNFLTF 372

  Fly   327 ENPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRGRCGEQHGLLRVI----FSALGDKNGLT 382
            ||.:||.||:....||.|||.....:|.|:      |...|||.:    |.|...:|.:|
Worm   373 ENKKSIEAKLAYAIEHNLGGVWIHLVDKDN------ENEELLRAVASKKFCASESENKVT 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	90/376 (24%)
		Glyco_hydro_18	47..355	CDD:279094	77/326 (24%)
		ChtBD2	394..438	CDD:214696
chil-18	NP_496024.2	Glyco_18	70..401	CDD:214753	83/349 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3021
OMA	1	1.010	-	-		QHG28694
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.700