DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht12 and cht-2

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_495798.2	Gene:	cht-2 / 174363	WormBaseID:	WBGene00011757	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	473	Identity:	115/473 - (24%)
Similarity:	189/473 - (39%)	Gaps:	113/473 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 THLVLG-------SGIGVDGDSGELRITDKILLLEKDKLSSVKTMKWDSIKKVMFTIGGWEEDSS 110
            ||||..       ..:.::||:.:.|:         :.:..|.:...|  .|:::.:||| |:|.
Worm    55 THLVFAFFVVDSDGSVKLEGDAAKARL---------EHVKEVASRHPD--LKLLYAVGGW-ENSQ 107

  Fly   111 SFSRMVASPKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLLG---GHPDDRQNFVILLEELGLIF 172
            .||.:.|...:|....|:.::.:..:|||||.|||.||...|   |.|.||:|:|.|:.||
Worm   108 YFSVLTADHSRRSILISNFVKVIKEYGFDGVDIDWEYPVTGGAVEGTPADRRNYVNLMREL---- 168

  Fly   173 RKNQL---------ILMVAVLGRRDNRILE-SYNIPEIVNHSDFIHLMMHDEQDPYHLRL-AYN- 225
             :|:|         ..:::..|...:.:|: .|::.:::.:.||:::|.:|....:..:. ||.
Worm   169 -RNELRDLESETGKSYLISFAGAAGHWVLKPGYDLQQLMKYCDFVNVMSYDYFGAWASKWGAYTG 232

  Fly   226 --APL-----------VGYEGSVTDSIMHWKRNGGAPEKLILGIPLFVRSFTMDRNQSTVGSACK 277
              |||           :....::.|.....|    |.:|:.:|:|.:.|.:      ..||.|..
Worm   233 PPAPLQFAMPKKFSGRMNVHATMKDYSCQIK----ATDKINMGVPFYGRFW------KNVGDAVD 287

  Fly   278 GPGRQTKQSHRPGFMTYNE----------WCVQQSKW---SRMFDQLAKVPYATRGDQ--WVSYE 327
                .|....|....|.:|          |.....|:   ...|...:|.|:....:|  :|.||
Worm   288 ----STDDMWRTATATNSEGTKFEGGDVQWRDLHEKFDTTKTKFHSGSKTPFIWLSEQKTFVGYE 348

  Fly   328 NPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRGR----------CGEQHGLLRVIFSALGDKNGLT 382
            |..|:..|:..:.|:.:||.|.|.||.||.:|.          |...........|.:.||...|
Worm   349 NAESLKHKVDYIVENNIGGVMIWAIDFDDDQGTLLNSAAAESICTTSTKSFNYKCSPVDDKRWWT 413

  Fly   383 TEKPTTEASGLCPHDGFSRDGW------------DCRLYHECRDGERIYY--ECLEGQY-FDENQ 432
            .: ...|.:|:|.......||:            .|..|..|..|.....  ||::  | .|.|.
Worm   414 YD-DNEELAGMCGKSSPLIDGYYPVCDPDDPGHACCGKYGYCGSGAEFCSCPECID--YGADPNL 475

  Fly   433 IVCRPAAEVKCDQNFVIW 450
            |:..|   ||..|. :.|
Worm   476 ILKEP---VKPSQK-ITW 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:299167	92/381 (24%)
		Glyco_hydro_18	47..355	CDD:279094	87/351 (25%)
		ChtBD2	394..438	CDD:214696	13/58 (22%)
cht-2	NP_495798.2	Glyco_18	33..376	CDD:214753	87/351 (25%)
		GH18_chitinase-like	35..376	CDD:299167	87/351 (25%)
		ChtBD1_GH18_2	418..469	CDD:211315	11/52 (21%)
		ChtBD1_GH18_2	496..547	CDD:211315
		ChtBD1_GH18_2	567..618	CDD:211315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820