Protein Alignment Cht12 and CHIT1

DIOPT Version :10

• Sequence 1: NP_726022.1
• Gene: Cht12 / 246535
• FlyBaseID: FBgn0050293
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: XP_047298855.1
• Gene: CHIT1 / 1118
• HGNCID: 1936
• Length: 481
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 134/467 - (28%)
• Similarity: 213/467 - (45%)
• Gaps: 70/467 - (14%)

  Fly     8 FMIMIFLICGCIAKEYNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRI 72
            ||:::.:..|..||   :.|.:...:.|.:|.::|....||..|||||:.......:........
Human    25 FMVLLMIPWGSAAK---LVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEW 86

  Fly    73 TDKILLLEKDKLSSVKTMKWDSIKKVMFTIGGWEEDSSSFSRMVASPKKRDNFYSSMLEFMFRWG 137
            .|:.|..|.:.|.     |.:...|.:..||||...:..|:.|||:...|..|.:|.:.|:.::.
Human    87 NDETLYQEFNGLK-----KMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYS 146

  Fly   138 FDGVQIDWRYPTLLGGHPDDRQNFVILLEELGLIFR-------KNQLILMVAVLGRRDNRILESY 195
            |||:.:||.||...|....|::.|..|:::|...|:       |.:|:|..||...: ..:...|
Human   147 FDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQ-TYVDAGY 210

  Fly   196 NIPEIVNHSDFIHLMMHDEQDPYHLRLAYNAPLV------GYEGS--VTDSIMHWKRNGGAPEKL 252
            .:.:|..:.||::||.:|....:.....:|:||.      |...|  |..::..|.:.|....||
Human   211 EVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKL 275

  Fly   253 ILGIPLFVRSFTMDRNQST-VGSACKG---PGRQTKQSHRPGFMTYNEWCVQQSKW-----SRMF 308
            |||:|.:.||||:..:..| ||:...|   ||..||:.   |.:.|.|.|    .|     .|:.
Human   276 ILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEG---GMLAYYEVC----SWKGATKQRIQ 333

  Fly   309 DQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRG-RCGE-QHGLLRVI 371
            ||  ||||..|.:|||.:::..|...|:..|::..|||||.|.:|:|||.| .|.: ::.|::.:
Human   334 DQ--KVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTL 396

  Fly   372 FSALG-------------DKNGLTTEKPTTEASGLCP-HDGFSR---DGWDCRLYHECRDGERIY 419
            ...|.             .|.|    :|:....|..| .|.|.:   ||    ||...|: ...:
Human   397 RQELSLPYLPSGTPELEVPKPG----QPSEPEHGPSPGQDTFCQGKADG----LYPNPRE-RSSF 452

  Fly   420 YECLEGQYFDEN 431
            |.|..|:.|.::
Human   453 YSCAAGRLFQQS 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cht12	NP_726022.1	GH18_chitinase-like	25..375	CDD:471972	112/375 (30%)
		ChtBD2	394..438	CDD:214696	12/42 (29%)
CHIT1	XP_047298855.1	GH18_chitolectin_chitotriosidase	39..400	CDD:119351	112/375 (30%)
		ChtBD2	434..481	CDD:214696	10/36 (28%)