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Protein Alignment Cht12 and CHI3L1

DIOPT Version :9

Sequence 1:	NP_726022.1	Gene:	Cht12 / 246535	FlyBaseID:	FBgn0050293	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001267.2	Gene:	CHI3L1 / 1116	HGNCID:	1932	Length:	383	Species:	Homo sapiens

Alignment Length:	390	Identity:	121/390 - (31%)
Similarity:	193/390 - (49%)	Gaps:	67/390 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FMIMIFLICGCIAKEYNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRI 72
            |::::.|.| |.|  |.:.|.|...|.|.:|....|...||..||||::. |...:..|
Human    10 FVVLVLLQC-CSA--YKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIY-SFANISND------ 64

  Fly    73 TDKILLLEKDKLSSVKTMKWDSIK---------------KVMFTIGGWEEDSSSFSRMVASPKKR 122
                         .:.|.:|:.:.               |.:.::|||...|..||::.::.:.|
Human    65 -------------HIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSR 116

  Fly   123 DNFYSSMLEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEELGLIFRK-----NQLILMVA 182
            ..|..|:..|:...||||:.:.|.||    |. .|:|:|..|::|:...|.|     .:.:|:.|
Human   117 RTFIKSVPPFLRTHGFDGLDLAWLYP----GR-RDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSA 176

  Fly   183 VLGRRDNRILESYNIPEIVNHSDFIHLMMHDEQDPYHLRLAYNAPLV-GYEG------SVTDSIM 240
            .|......|..||:|.:|..|.|||.:|.:|....:.....:::||. |.|.      |.||..:
Human   177 ALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAV 241

  Fly   241 HWKRNGGAP-EKLILGIPLFVRSFTMDRNQSTVGSACKG---PGRQTKQSHRPGFMTYNEWC--V 299
            .:....||| .||::|||.|.||||:..:::.||:...|   |||.||::   |.:.|.|.|  :
Human   242 GYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEA---GTLAYYEICDFL 303

  Fly   300 QQSKWSRMFDQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRGR-CGE 363
            :.:...|:..|  :|||||:|:|||.|::..|:.:|:..|::.:|.|||.|.:|:|||:|. ||:
Human   304 RGATVHRILGQ--QVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQ 366

Fly 364 363
Human 367 366

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.