DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30291 and Cdk5rap3

DIOPT Version :9

Sequence 1:	NP_726016.1	Gene:	CG30291 / 246534	FlyBaseID:	FBgn0050291	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_084524.1	Gene:	Cdk5rap3 / 80280	MGIID:	1933126	Length:	503	Species:	Mus musculus

Alignment Length:	529	Identity:	183/529 - (34%)
Similarity:	275/529 - (51%)	Gaps:	55/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NESEIPIDIHTLKLQDWLISRRIVPKNVQQELREIHRKISNALQDMPSNEQLIKLLARTNINYYH 66
            :...:||||.|.||.|||:.||......|..:..|..||:.|:||||.::::.:||:.:.|:|:|
Mouse     3 DHQHVPIDIQTSKLLDWLVDRRHCNLKWQSLVLTIREKINTAIQDMPESQEIAQLLSGSYIHYFH 67

  Fly    67 VKEIIEILKQTEKDTKSVFGTYGSQRMKDWQEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQ 131
            ...|:::||.||..||::||.|.||||||||||..||||:.|||.|...:.||||:||||.::||
Mouse    68 CLRIVDLLKGTEASTKNIFGRYSSQRMKDWQEIVSLYEKDNTYLVELCSLLVRNVSYEIPSLKKQ 132

  Fly   132 MARLEQQADETQKRAHDLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLPELYDKSLVGI 196
            :|:.:|...|..::..:.....:::........:|.|:.|||:..|.:.::..||....:...|.
Mouse   133 IAKCQQLQQEYSRKEEEGQAGAAEMREQFYHSCKQYGITGDNVRRELLALVKDLPSQLAEIGAGA 197

  Fly   197 ANIQPGIDLYAEV------SGNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEGN 255
            .::...||||...      |..:||||:|.::.:.||:|||::.....|..||.|    .|.|
Mouse   198 QSLGEAIDLYQACVEFVCDSPTEQVLPMLRYVQKKGNSTVYEWRTGTEPSVVERP----QLEE-- 256

  Fly   256 ASKDDNAVAEIDFGTDDNGGTSSTVSAEIIDYGDFG------SGDLPESDGGNIDWGI--ESAPT 312
                                ....|..:.||:||||      ||.:.|:.|  |||||  ||...
Mouse   257 --------------------PPEQVQEDEIDWGDFGVEAVSDSGIVAETPG--IDWGISLESEAK 299

  Fly   313 DAVEINFD-----IPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMR 372
            ||.....|     ....|..::..||....|.|:|..|.|||:.|..|::|:||:.|||.||..|
Mouse   300 DAGADKIDWGDDAAAASEITVLETGTEAPEGVARGSDALTLLEYPETRNQFIDELMELEIFLSQR 364

  Fly   373 IYELKQLESSSDIM----FSLMDNIAT-HDGESIWKILVSVEKIIQQTSDKQTQHLFQLKHSPKY 432
            ..|:.:   .:||:    |.|...|.. ...|.:..::.:::::|.:.:..:.||||.:..||:|
Mouse   365 AVEMSE---EADILSVSQFQLAPAILQGQTKEKMLSLVSTLQQLIGRLTSLRMQHLFMILASPRY 426

  Fly   433 ANMLATKLQQMTKAVEKLRATREALKQLTIELREQRQDLNPVLEELIAQTRTLQSHIEKDISKRY 497
            .:.:...|||..|..:.|...:|.:.:...|..:::..|.|.|:.|:.:||.||..||.||||||
Mouse   427 VDRVTEFLQQKLKQSQLLALKKELMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRY 491

  Fly   498 KNRVVNLMG 506
            ..|.|||||
Mouse   492 SGRPVNLMG 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30291	NP_726016.1	DUF773	3..506	CDD:283293	181/526 (34%)
Cdk5rap3	NP_084524.1	DUF773	5..500	CDD:283293	181/525 (34%)
Cdk5rap3	NP_084524.1	Required for interaction with UFL1 and mediates interaction with CHEK1. /evidence=ECO:0000250\|UniProtKB:Q96JB5	268..503		83/238 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846159
Domainoid	1	1.000	284	1.000	Domainoid score	I1629
eggNOG	1	0.900	-	-		E1_KOG2607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12718
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2835
Isobase	1	0.950	-	0	Normalized mean entropy	S4484
OMA	1	1.010	-	-		QHG55506
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006409
OrthoInspector	1	1.000	-	-		oto94732
orthoMCL	1	0.900	-	-		OOG6_105202
Panther	1	1.100	-	-	LDO	PTHR14894
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.750