Protein Alignment CG30291 and CDK5RAP3

DIOPT Version :9

• Sequence 1: NP_726016.1
• Gene: CG30291 / 246534
• FlyBaseID: FBgn0050291
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001265126.1
• Gene: CDK5RAP3 / 80279
• HGNCID: 18673
• Length: 531
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 191/520 - (36%)
• Similarity: 283/520 - (54%)
• Gaps: 34/520 - (6%)

  Fly     2 NESEIPIDIHTLKLQDWLISRRIVPKNVQQELREIHRKISNALQDMPSNEQLIKLLARTNINYYH 66
            :...:||||.|.||.|||:.||......|..:..|..||:.|:||||.:|::.:||:.:.|:|:|
Human    28 DHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVLTIREKINAAIQDMPESEEIAQLLSGSYIHYFH 92

  Fly    67 VKEIIEILKQTEKDTKSVFGTYGSQRMKDWQEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQ 131
            ...|:::||.||..||::||.|.||||||||||..||||:.|||.|.:.:.|||||||||.::||
Human    93 CLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQ 157

  Fly   132 MARLEQQADETQKRAHDLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLP-ELYDKSLVG 195
            :|:.:|...|..::..:.....:::........:|.|:.|:|:..|.:.::..|| :|.:.....
Human   158 IAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAA 222

  Fly   196 IANIQPGIDLY-AEV-----SGNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEG 254
            ..::...||:| |.|     |..:||||:|..:.:.||:|||::.....|..||.|    :|.|.
Human   223 QQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERP----HLEEL 283

  Fly   255 NASKDDNAVAEIDFGTDD-NGGTSSTVSAEI--IDYGDFGSGDLPESDGGNIDWGIESAPTDAVE 316
            .....::|:...|||.:. :.||.|.:|||.  ||:|.|...|..:..|..||||     .|||.
Human   284 PEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWG-----DDAVA 343

  Fly   317 INFDIPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMRIYELKQLES 381
            :       :..::..||....|.|:|..|.|||:....|::||||:.|||.||..|..||.:
Human   344 L-------QITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSE--- 398

  Fly   382 SSDIM----FSLMDNIATHDGESIWKILVSV-EKIIQQTSDKQTQHLFQLKHSPKYANMLATKLQ 441
            .:|::    |.|...|.....:.....:||| |.:|.:.:..|.||||.:..||:|.:.:...||
Human   399 EADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQ 463

  Fly   442 QMTKAVEKLRATREALKQLTIELREQRQDLNPVLEELIAQTRTLQSHIEKDISKRYKNRVVNLMG 506
            |..|..:.|...:|.:.|...|..|::..|.|.|:.|:.:|:.||..||.||||||..|.|||||
Human   464 QKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMG 528

  Fly   507  506
            Human   529  528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30291	NP_726016.1	DUF773	3..506	CDD:283293	189/517 (37%)
CDK5RAP3	NP_001265126.1	DUF773	30..528	CDD:283293	189/516 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155717
Domainoid	1	1.000	294	1.000	Domainoid score	I1497
eggNOG	1	0.900	-	-		E1_KOG2607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12718
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2772
Isobase	1	0.950	-	0	Normalized mean entropy	S4484
OMA	1	1.010	-	-		QHG55506
OrthoDB	1	1.010	-	-		D397659at33208
OrthoFinder	1	1.000	-	-		FOG0006409
OrthoInspector	1	1.000	-	-		oto91146
orthoMCL	1	0.900	-	-		OOG6_105202
Panther	1	1.100	-	-	LDO	PTHR14894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4513
SonicParanoid	1	1.000	-	-		X4673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790