DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30291 and cdk5rap3

DIOPT Version :9

Sequence 1:	NP_726016.1	Gene:	CG30291 / 246534	FlyBaseID:	FBgn0050291	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001002105.1	Gene:	cdk5rap3 / 415195	ZFINID:	ZDB-GENE-040625-90	Length:	507	Species:	Danio rerio

Alignment Length:	525	Identity:	182/525 - (34%)
Similarity:	280/525 - (53%)	Gaps:	43/525 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NESEIPIDIHTLKLQDWLISRRIVPKNVQQELREIHRKISNALQDMPSNEQLIKLLARTNINYYH 66
            |...:||||.|.||.|||:.||......|..:..|..||:.|:||||.||::.:||:.:.|:::|
Zfish     3 NIQNLPIDIQTSKLLDWLVDRRHCTLKWQSAVMTIREKINAAIQDMPENEEIKQLLSGSYIHHFH 67

  Fly    67 VKEIIEILKQTEKDTKSVFGTYGSQRMKDWQEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQ 131
            ..:|||:||.||..||::||.|.||||||||||..:|||:..||||.|.|.||||:||.|.:|||
Zfish    68 CLQIIEVLKGTEASTKNIFGRYSSQRMKDWQEIVSMYEKDNVYLAEMASILVRNVSYEGPALRKQ 132

  Fly   132 MARLEQQADETQKRAHDLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLPELYDKSLVGI 196
            :::.:|...|..:|..:.....:.:...:.|..:|.|:||:|:..|....:..||.:.:::....
Zfish   133 VSKAQQLQQELSRRELECQSGSADMRERYYAACKQYGIKGENVARELQAQVKDLPVVLEETGKKA 197

  Fly   197 ANIQPGIDLYAEVS-----GNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEGNA 256
            |.::..|:.|...:     .:::|||:|..:.:.||||||:......|..||.|.:.      .|
Zfish   198 ACLKDAIEFYTAFTKFVSDWSEEVLPLLRFVQKKGNTTVYERKTGNVPKVVERPVME------EA 256

  Fly   257 SKDDNAVAEIDFGTDDNGGTSSTVSAEI---------IDYGDFGSGDLPESDGGNIDWG-IESAP 311
            ..|......||:|  |.|..:.|.|.|:         :|:|........|:.||.|:|| .||||
Zfish   257 PPDVVTEETIDWG--DLGSGAGTGSEEVNFGISVEDGVDWGIGLESGTEETSGGGINWGDSESAP 319

  Fly   312 TDAVEINFDIPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMRIYEL 376
            .            |..:|..||....|.|:|:.|.:||::...|.:|::|:.|||.||..|:.|:
Zfish   320 L------------EIEVVDVGTDCPDGVARGEDALSLLENSQTRSQFINELKELEMFLCQRLSEM 372

  Fly   377 KQLESSSDIM----FSLMDN-IATHDGESIWKILVSVEKIIQQTSDKQTQHLFQLKHSPKYANML 436
            ::   ..|::    |.|..: |.....:.:..:|..|.:::...:..:.||||.::.||:|...:
Zfish   373 RE---EGDLVAMSQFQLAPSVIQAQTPQRVQVMLADVRELLNGLTSVRMQHLFMIQASPRYVERV 434

  Fly   437 ATKLQQMTKAVEKLRATREALKQLTIELREQRQDLNPVLEELIAQTRTLQSHIEKDISKRYKNRV 501
            :..|:|..|..:.:...|..|.:...|..|::..|.|.::.|.|:|:.||..||.||||||.||.
Zfish   435 SELLRQKLKQADIMVLKRGTLAEKRQEALEEQAKLEPRIDLLAARTKELQKLIEADISKRYNNRP 499

  Fly   502 VNLMG 506
            |||||
Zfish   500 VNLMG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30291	NP_726016.1	DUF773	3..506	CDD:283293	179/522 (34%)
cdk5rap3	NP_001002105.1	DUF773	4..504	CDD:283293	179/522 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590894
Domainoid	1	1.000	284	1.000	Domainoid score	I1599
eggNOG	1	0.900	-	-		E1_KOG2607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12718
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2840
OMA	1	1.010	-	-		QHG55506
OrthoDB	1	1.010	-	-		D397659at33208
OrthoFinder	1	1.000	-	-		FOG0006409
OrthoInspector	1	1.000	-	-		oto40653
orthoMCL	1	0.900	-	-		OOG6_105202
Panther	1	1.100	-	-	LDO	PTHR14894
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4513
SonicParanoid	1	1.000	-	-		X4673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840