DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30287 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_726083.1	Gene:	CG30287 / 246530	FlyBaseID:	FBgn0050287	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	288	Identity:	80/288 - (27%)
Similarity:	120/288 - (41%)	Gaps:	50/288 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FLKVQGQP-------HLLDPQCVTARSEPGLYRVINGKPADLFSNPWMVIIIERGMMKCGGSLIT 73
            ||:...||       .::..:|....:.|...|::.|:.......||...:.......||||::.
Human   185 FLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLA 249

  Fly    74 PRYVLTAAHCKSETKSQLTVRLGDYDVNQAVDCSSYGCIPRPREINVTRTYVPSHYTNFRKN--- 135
            ||:|:|||||....:   ..||..:.|:..:  .|:..: ||.:..:....:| |.....:|
Human   250 PRWVVTAAHCMHSFR---LARLSSWRVHAGL--VSHSAV-RPHQGALVERIIP-HPLYSAQNHDY 307

  Fly   136 DIALLRLETTVQYGDNIRSICL-------LMGDYTWSSNILKNLVKFNTTGWGRT--ESRINSPV 191
            |:|||||:|.:.:.|.:.::||       ..|...|.|            |||.|  ....:|.:
Human   308 DVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVS------------GWGHTHPSHTYSSDM 360

  Fly   192 LQQASLTHHHLSYC--AQVFGKQLDKSHICVASSTG--STCQGDSGGPLTARVRIGSERRVILFG 252
            ||...:.......|  :.|:...|....:|.....|  ..|||||||||..  ..|...|::  |
Human   361 LQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVC--PDGDTWRLV--G 421

  Fly   253 VVSYGAVHCFGPT---VYTNVIHFANWI 277
            |||:|. .|..|.   ||..|..|.:||
Human   422 VVSWGR-GCAEPNHPGVYAKVAEFLDWI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30287	NP_726083.1	Tryp_SPc	41..277	CDD:214473	72/254 (28%)
CG30287	NP_726083.1	Tryp_SPc	42..280	CDD:238113	73/255 (29%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	5/27 (19%)
		Tryp_SPc	217..448	CDD:214473	72/254 (28%)
		Tryp_SPc	218..451	CDD:238113	73/255 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910