DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30287 and PRSS1

DIOPT Version :9

Sequence 1:	NP_726083.1	Gene:	CG30287 / 246530	FlyBaseID:	FBgn0050287	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	255	Identity:	68/255 - (26%)
Similarity:	108/255 - (42%)	Gaps:	54/255 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RVINGKPADLFSNPWMVIIIERGMMKCGGSLITPRYVLTAAHCKSETKSQLTVRLGDYDVNQAVD 105
            :::.|...:..|.|:.| .:..|...||||||..::|::|.||   .||::.||||::::.
Human   248 KIVGGYNCEENSVPYQV-SLNSGYHFCGGSLINEQWVVSAGHC---YKSRIQVRLGEHNIE---- 304

  Fly   106 CSSYGCIPRPREINVTRTYVPSHYTNFRK---NDIALLRLETTVQYGDNIRSICLLMGDYTWSSN 167
                  :....|..:....:..|....||   |||.|::|.:.......:.:|.|........:.
Human   305 ------VLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTK 363

  Fly   168 ILKNLVKFNTTGWGRTESR----------INSPVLQQASLTHHHLSYCAQVFGKQLDKSHICVAS 222
            .|       .:|||.|.|.          :::|||.||.        |...:..::..:..||..
Human   364 CL-------ISGWGNTASSGADYPDELQCLDAPVLSQAK--------CEASYPGKITSNMFCVGF 413

  Fly   223 STG--STCQGDSGGPLTARVRIGSERRVILFGVVSY--GAVHCFGPTVYTNVIHFANWIE 278
            ..|  .:||||||||:....:        |.||||:  |......|.|||.|.::..||:
Human   414 LEGGKDSCQGDSGGPVVCNGQ--------LQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30287	NP_726083.1	Tryp_SPc	41..277	CDD:214473	66/252 (26%)
CG30287	NP_726083.1	Tryp_SPc	42..280	CDD:238113	68/254 (27%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	66/252 (26%)
		Tryp_SPc	249..467	CDD:238113	68/254 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910