DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30287 and HPN

DIOPT Version :9

Sequence 1:	NP_726083.1	Gene:	CG30287 / 246530	FlyBaseID:	FBgn0050287	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001362370.1	Gene:	HPN / 3249	HGNCID:	5155	Length:	417	Species:	Homo sapiens

Alignment Length:	255	Identity:	79/255 - (30%)
Similarity:	106/255 - (41%)	Gaps:	34/255 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RVINGKPADLFSNPWMVIIIERGMMKCGGSLITPRYVLTAAHC---KSETKSQLTVRLGDYDVNQ 102
            |::.|:...|...||.|.:...|...|||||::..:|||||||   ::...|:..|..|
Human   162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAG------ 220

  Fly   103 AVDCSSYGCIPRPREINVTRTYVPSHYTNFR-------KNDIALLRLETTVQYGDNIRSICL-LM 159
            ||..:|    |...::.|........|..||       .|||||:.|.:.:...:.|:.:|| ..
Human   221 AVAQAS----PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281

  Fly   160 GDYTWSSNILKNLVKFNTTGWGRTE-SRINSPVLQQASLTHHHLSYC--AQVFGKQLDKSHICVA 221
            |.......|.      ..||||.|: ....:.|||:|.:.......|  |..:|.|:.....|..
Human   282 GQALVDGKIC------TVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAG 340

  Fly   222 SSTG--STCQGDSGGPLTARVRIGSERRVILFGVVSYGAVHCFG--PTVYTNVIHFANWI 277
            ...|  ..||||||||......|....|..|.|:||:|......  |.|||.|..|..||
Human   341 YPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30287	NP_726083.1	Tryp_SPc	41..277	CDD:214473	77/253 (30%)
CG30287	NP_726083.1	Tryp_SPc	42..280	CDD:238113	78/254 (31%)
HPN	NP_001362370.1	Hepsin-SRCR	51..159	CDD:401275
HPN	NP_001362370.1	Tryp_SPc	163..400	CDD:238113	76/252 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910