DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30287 and HGF

DIOPT Version :9

Sequence 1:	NP_726083.1	Gene:	CG30287 / 246530	FlyBaseID:	FBgn0050287	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	254	Identity:	73/254 - (28%)
Similarity:	105/254 - (41%)	Gaps:	48/254 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RVINGKPADLFSNPWMVIIIERGMMKCGGSLITPRYVLTAAHC-KSETKSQLTVRLGDYDVNQAV 104
            ||:||.|... :..|||.:..|....||||||...:||||..| .|.........||.:||:...
Human   494 RVVNGIPTRT-NIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRG 557

  Fly   105 D--CSSYGCIPRPREINVTR-TYVPSHYTNFRKNDIALLRLETTVQYGDNIRSICLLMGDYTWSS 166
            |  |.        :.:||:: .|.|      ..:|:.|::|.......|.:.:|.|.....|
Human   558 DEKCK--------QVLNVSQLVYGP------EGSDLVLMKLARPAVLDDFVSTIDLPNYGCT--- 605

  Fly   167 NILKNLVKFNTTGWGRTESRINSPVLQQASL--------THHHLSYCAQVFGK-QLDKSHICV-A 221
              :......:..|||.|.......:|:.|.|        :.||.       || .|::|.||. |
Human   606 --IPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHR-------GKVTLNESEICAGA 661

  Fly   222 SSTGS-TCQGDSGGPLTARVRIGSERRVILFGVV--SYGAVHCFGPTVYTNVIHFANWI 277
            ...|| .|:||.||||.....   :.|::| ||:  ..|......|.::..|.::|.||
Human   662 EKIGSGPCEGDYGGPLVCEQH---KMRMVL-GVIVPGRGCAIPNRPGIFVRVAYYAKWI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30287	NP_726083.1	Tryp_SPc	41..277	CDD:214473	71/252 (28%)
CG30287	NP_726083.1	Tryp_SPc	42..280	CDD:238113	72/253 (28%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	71/252 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930