DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30287 and AgaP_AGAP000331

DIOPT Version :9

Sequence 1:	NP_726083.1	Gene:	CG30287 / 246530	FlyBaseID:	FBgn0050287	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_310784.4	Gene:	AgaP_AGAP000331 / 1271927	VectorBaseID:	AGAP000331	Length:	4655	Species:	Anopheles gambiae

Alignment Length:	190	Identity:	41/190 - (21%)
Similarity:	59/190 - (31%)	Gaps:	61/190 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KCGGSLITPRYVLTAAHC---KSETKSQLTVRLGDYDVNQAVDCSSYG----------------C 111
            |||.|       ||...|   ...|.|.......|.|     :|:.:|                |
Mosquito   303 KCGPS-------LTGGVCYCPAGRTLSPDNRTCADLD-----ECTVWGHCDQLCTNTDGSFSCAC 355

  Fly   112 IPRPREINVTRTYVP--SHYTNFRKNDIALLRLETTVQYGDNIRSICLLMGDYTWSSNILKNLVK 174
            ......:..||...|  |....|...|.|:||:..   :|.:.|.|....|....|.:..|||:.
Mosquito   356 ATGYTLMEKTRCVAPTASSLELFFAYDRAILRMSA---HGQDSRIIANATGASGLSYHYAKNLLY 417

  Fly   175 FNTTGWGRTESR-INSPVLQQASLTHHHLS-------------------YCAQVFGKQLD 214
                 |...::| :.|.||.......|..:                   |.|.:.|:::|
Mosquito   418 -----WSDIKTRKVQSQVLVDGGFGGHDFTLPGTWAPVAIAIDWVGDKLYVADLVGQKVD 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30287	NP_726083.1	Tryp_SPc	41..277	CDD:214473	41/190 (22%)
CG30287	NP_726083.1	Tryp_SPc	42..280	CDD:238113	41/190 (22%)
AgaP_AGAP000331	XP_310784.4	LDLa	35..68	CDD:238060
		LDLa	75..114	CDD:238060
		LDLa	170..205	CDD:238060
		LDLa	210..244	CDD:238060
		LDLa	249..287	CDD:238060
		vWFA	<325..366	CDD:294047	5/45 (11%)
		NHL	449..>556	CDD:302697	4/24 (17%)
		NHL repeat	449..486	CDD:271320	4/24 (17%)
		NHL repeat	492..530	CDD:271320
		FXa_inhibition	639..681	CDD:291342
		NHL	<723..881	CDD:302697
		NHL repeat	723..766	CDD:271320
		NHL repeat	767..803	CDD:271320
		LY	798..840	CDD:214531
		NHL repeat	805..845	CDD:271320
		LY	849..884	CDD:214531
		NHL repeat	852..881	CDD:271320
		FXa_inhibition	957..1011	CDD:291342
		LDLa	1030..1056	CDD:197566
		LDLa	1065..1099	CDD:238060
		LDLa	1103..1135	CDD:197566
		LDLa	1144..1179	CDD:238060
		LDLa	1184..1219	CDD:238060
		LDLa	1232..1263	CDD:238060
		LDLa	1267..1299	CDD:197566
		FXa_inhibition	1398..1429	CDD:291342
		LY	1501..1541	CDD:214531
		LY	1543..1587	CDD:214531
		Ldl_recept_b	1566..1604	CDD:278487
		LY	1588..1630	CDD:214531
		Ldl_recept_b	1889..1931	CDD:278487
		FXa_inhibition	2027..>2055	CDD:291342
		LY	2135..2181	CDD:214531
		LY	2182..2224	CDD:214531
		LY	2228..2268	CDD:214531
		NHL	<2464..2609	CDD:302697
		NHL repeat	2465..2500	CDD:271320
		NHL repeat	2503..2543	CDD:271320
		LY	2543..2585	CDD:214531
		NHL repeat	2552..2584	CDD:271320
		LDLa	2739..2773	CDD:238060
		LDLa	2778..2813	CDD:238060
		LDLa	2821..2854	CDD:197566
		LDLa	2906..2938	CDD:197566
		LDLa	2948..2987	CDD:197566
		LDLa	3000..3035	CDD:238060
		LDLa	3042..3076	CDD:238060
		LDLa	3082..3114	CDD:197566
		vWFA	<3118..3158	CDD:294047
		vWFA	<3156..3196	CDD:294047
		LY	3281..3321	CDD:214531
		Ldl_recept_b	3341..3383	CDD:278487
		LY	3372..3409	CDD:214531
		LY	3409..3451	CDD:214531
		FXa_inhibition	3480..3532	CDD:291342
		LDLa	3536..3569	CDD:238060
		LDLa	3578..3612	CDD:238060
		LDLa	3616..3648	CDD:197566
		LDLa	3660..3690	CDD:238060
		LDLa	3700..3734	CDD:197566
		LDLa	3745..3774	CDD:197566
		LDLa	3786..3820	CDD:238060
		LDLa	3825..3859	CDD:238060
		LDLa	3869..3900	CDD:197566
LDLa	3916..3944	CDD:238060
LDLa	3959..3990	CDD:238060
vWFA	<4030..4068	CDD:294047
NHL	4148..>4291	CDD:302697
NHL repeat	4163..4208	CDD:271320
NHL repeat	4212..4248	CDD:271320
Ldl_recept_b	4222..4262	CDD:278487
NHL repeat	4253..4291	CDD:271320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910