DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30281 and angptl2a

DIOPT Version :9

Sequence 1:	NP_726164.1	Gene:	CG30281 / 246525	FlyBaseID:	FBgn0050281	Length:	291	Species:	Drosophila melanogaster
Sequence 2:	NP_001025401.1	Gene:	angptl2a / 569092	ZFINID:	ZDB-GENE-080721-15	Length:	525	Species:	Danio rerio

Alignment Length:	233	Identity:	93/233 - (39%)
Similarity:	131/233 - (56%)	Gaps:	16/233 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TEERGSH-----ETINP-SSCLAA---GINSNGIHVIEVPGLEP-FPVYCDTRLAGSGWTVIQRR 108
            ||:..:|     :...| ..||.|   |.:::|:.:::...... ..|:||.|....||||||||
Zfish   290 TEQSETHSFSTDKLSGPFKDCLQALEEGHSNSGMFLLKPENTNKLMQVWCDQRHDPGGWTVIQRR 354

  Fly   109 QDGSENFYRCWEEYSQGFGELSGEFFMGLEKLHFLTTAEPYELFVYMEDFNGVVHDARYEDFAIG 173
            .|||.||:|.||.|.||||.:.||:::|||.:::||....|:|.|.:||::|....|.|..|.:.
Zfish   355 MDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTLEDWSGRKTFAEYASFRLE 419

  Fly   174 NASASYALSVLGKYSGDAGDSLRYHKGMPFSTFDHDD---TGHGCARIYVGAWWYDQCQRSNLNG 235
            ..:..|.:.| |:|.|:||||:.:|.|..|:|.|.|.   ||: ||....|.|||:.|..|||||
Zfish   420 PEADFYKMRV-GRYHGNAGDSMTWHNGKQFTTLDRDHDAYTGN-CAHYQKGGWWYNACAHSNLNG 482

  Fly   236 QYLEGGRFEPKMSGRGITWMSWRGYDYGYKFVQMMIRP 273
            .:..||.:..:... |:.|..:||..|..|.|.|||||
Zfish   483 VWYRGGHYRSRYQD-GVYWAEFRGGSYSLKKVTMMIRP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30281	NP_726164.1	FReD	63..274	CDD:238040	90/219 (41%)
angptl2a	NP_001025401.1	DUF1875	<50..>147	CDD:286100
		Fib_alpha	119..215	CDD:285864
		FReD	305..519	CDD:238040	88/216 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6515
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810