DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30281 and Tnn

DIOPT Version :9

Sequence 1:	NP_726164.1	Gene:	CG30281 / 246525	FlyBaseID:	FBgn0050281	Length:	291	Species:	Drosophila melanogaster
Sequence 2:	NP_808507.2	Gene:	Tnn / 329278	MGIID:	2665790	Length:	1560	Species:	Mus musculus

Alignment Length:	298	Identity:	101/298 - (33%)
Similarity:	146/298 - (48%)	Gaps:	44/298 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SGGSLLSTAQSNKLD---LVY-------KKAESMVSSLKIRLEELKQ---------SYKEITEER 57
            |||.|.....|.::|   |.|       |:.|......:..|::|:|         ::|.....|
Mouse  1249 SGGVLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQRSR 1313

  Fly    58 GSHETI--------NPSSCLAAGINSN---GIHVIEVPG--LEPFPVYCDTRLAGSGWTVIQRRQ 109
            ....|:        :||.|.....|:|   |::.|.:.|  ..|..||||....|.||.|.|||.
Mouse  1314 TVSTTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRN 1378

  Fly   110 DGSENFYRCWEEYSQGFGELSGEFFMGLEKLHFLTTAEP--YELFVYMEDFNGVVHDARYEDFAI 172
            .|..:|::.|..|.:|||:...||::||:|||.|||...  ||:...::.||...: |.|:.|.:
Mouse  1379 TGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFNESAY-AVYDFFQV 1442

  Fly   173 GNASASYALSVLGKYSGDAGDSLRYHKGMPFSTFDHDD--TGHGCARIYVGAWWYDQCQRSNLNG 235
            .::...|.||| |||.|.|||:|.||.|..|:|||.|:  ....||..:.|.|||..|..:|.||
Mouse  1443 ASSKERYKLSV-GKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNG 1506

  Fly   236 QYLEGGRFEPKMSGRGITWMSWRGYDYGYKFVQMMIRP 273
            :|.|....|      |:.|..|:|:::...:|::.|||
Mouse  1507 KYGETKHSE------GVNWEPWKGHEFSIPYVELKIRP 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30281	NP_726164.1	FReD	63..274	CDD:238040	85/228 (37%)
Tnn	NP_808507.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470
		fn3	796..875	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..888
		fn3	884..961	CDD:278470
		fn3	972..1049	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1063
		FN3	1060..1136	CDD:214495
		fn3	1148..1225	CDD:278470
		fn3	1236..1313	CDD:278470	14/63 (22%)
		FReD	1327..1539	CDD:238040	85/220 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810