DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30281 and FGB

DIOPT Version :9

Sequence 1:	NP_726164.1	Gene:	CG30281 / 246525	FlyBaseID:	FBgn0050281	Length:	291	Species:	Drosophila melanogaster
Sequence 2:	NP_005132.2	Gene:	FGB / 2244	HGNCID:	3662	Length:	491	Species:	Homo sapiens

Alignment Length:	291	Identity:	91/291 - (31%)
Similarity:	144/291 - (49%)	Gaps:	55/291 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SMVSSLKIRLEELKQSYKEITEERGSHETINPSSC-------------LAAGINSNGIHVIEV-P 84
            |::.:|:.::::|:   .:::.:.....|....||             :..|..::.:::|:. .
Human   200 SILENLRSKIQKLE---SDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDS 261

  Fly    85 GLEPFPVYCDTRLAGSGWTVIQRRQDGSENFYRCWEEYSQGFGE------------LSGEFFMGL 137
            .::|:.||||......||||||.|||||.:|.|.|:.|.||||.            |.||:::|.
Human   262 SVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGN 326

  Fly   138 EKLHFLTTAEPYELFVYMEDFNGVVHDARYEDFAIGNASASYALSVLGKYSGDAGDSL------- 195
            :|:..||...|.||.:.|||:.|....|.|..|.:.|.:..|.:|| .||.|.||::|
Human   327 DKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISV-NKYRGTAGNALMDGASQL 390

  Fly   196 -------RYHKGMPFSTFDHDDTG-------HGCARIYVGAWWYDQCQRSNLNGQYLEGGRFEPK 246
                   ..|.||.|||:|.|:.|       ..|::...|.|||::|..:|.||:|..||::...
Human   391 MGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWD 455

  Fly   247 MSGR----GITWMSWRGYDYGYKFVQMMIRP 273
            |:..    |:.||:|:|..|..:.:.|.|||
Human   456 MAKHGTDDGVVWMNWKGSWYSMRKMSMKIRP 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30281	NP_726164.1	FReD	63..274	CDD:238040	87/262 (33%)
FGB	NP_005132.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..75
		Beta-chain polymerization, binding distal domain of another fibrin	45..47
		Fib_alpha	92..234	CDD:312286	6/36 (17%)
		FReD	237..486	CDD:294064	83/249 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910