DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30281 and Fcna

DIOPT Version :9

Sequence 1:	NP_726164.1	Gene:	CG30281 / 246525	FlyBaseID:	FBgn0050281	Length:	291	Species:	Drosophila melanogaster
Sequence 2:	NP_032021.1	Gene:	Fcna / 14133	MGIID:	1340905	Length:	334	Species:	Mus musculus

Alignment Length:	231	Identity:	94/231 - (40%)
Similarity:	126/231 - (54%)	Gaps:	19/231 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KEITE---ERGSHETINPSSC---LAAGINSNGIHVIEVPGLEPFPVYCDTRLAGSGWTVIQRRQ 109
            ||:.:   :||      |.||   |..||...|.:.|.:|...|..|.||..:.|.||||.|||.
Mouse   112 KELGDTLCQRG------PRSCKDLLTRGIFLTGWYTIHLPDCRPLTVLCDMDVDGGGWTVFQRRV 170

  Fly   110 DGSENFYRCWEEYSQGFGELSGEFFMGLEKLHFLTTAEPYELFVYMEDFNGVVHDARYEDFAIGN 174
            |||.:|:|.|:.|.:|||.|..||::|.:.||.||.....||.|.::||.|....|:|..|.:..
Mouse   171 DGSIDFFRDWDSYKRGFGNLGTEFWLGNDYLHLLTANGNQELRVDLQDFQGKGSYAKYSSFQVSE 235

  Fly   175 ASASYALSVLGKY-SGDAGDSLRYHKGMPFSTFDHDDTGH--GCARIYVGAWWYDQCQRSNLNGQ 236
            ....|.|: ||:: .|.|||||..|..|.|:|.|.|:..:  .||.::.|||||..|.:|||||:
Mouse   236 EQEKYKLT-LGQFLEGTAGDSLTKHNNMSFTTHDQDNDANSMNCAALFHGAWWYHNCHQSNLNGR 299

  Fly   237 YLEGGRFEPKMSGRGITWMSWRGYDYGYKFVQMMIR 272
            ||.|..   :....||.|.:.:|:.|.||..:|.||
Mouse   300 YLSGSH---ESYADGINWGTGQGHHYSYKVAEMKIR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30281	NP_726164.1	FReD	63..274	CDD:238040	90/216 (42%)
Fcna	NP_032021.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..117		2/4 (50%)
		Collagen	65..106	CDD:189968
		FReD	123..332	CDD:238040	88/212 (42%)
		A domain, contributes to trimerization. /evidence=ECO:0000250	123..162		14/38 (37%)
		B domain, contributes to trimerization. /evidence=ECO:0000250	163..251		37/88 (42%)
		Carbohydrate-binding. /evidence=ECO:0000250\|UniProtKB:O00602	290..292		0/1 (0%)
		P domain. /evidence=ECO:0000250\|UniProtKB:O00602	325..334		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I3330
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3887
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000029
OrthoInspector	1	1.000	-	-		otm43211
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760