DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30281 and FGL2

DIOPT Version :9

Sequence 1:	NP_726164.1	Gene:	CG30281 / 246525	FlyBaseID:	FBgn0050281	Length:	291	Species:	Drosophila melanogaster
Sequence 2:	NP_006673.1	Gene:	FGL2 / 10875	HGNCID:	3696	Length:	439	Species:	Homo sapiens

Alignment Length:	307	Identity:	104/307 - (33%)
Similarity:	144/307 - (46%)	Gaps:	58/307 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AQSNKLDLVYKKAESMVSSLKIRLEELK-------QSY------------------------KEI 53
            ::.|||....|.|:..::.|..|||:|.       ::|                        :|.
Human   135 SEVNKLSSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANLTFVVNSLDGKCSKCPSQEQ 199

  Fly    54 TEERGSHETI--NPSSCLAAGINSNGIH-VIEVPGLEPFPVYCDTRLAGSGWTVIQRRQDGSENF 115
            .:.|.....|  :.|...|.|..|:..: |...|....|.||||....|.||||:|.|.|||.||
Human   200 IQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNF 264

  Fly   116 YRCWEEYSQGFGELSGEFFMGLEKLHFLTTAEPYELFVYMEDFNGVVHDARYEDFAIGNASASYA 180
            .|.|::|..|||.|..||::|.:|:|.||.::...|.:.:||||||...|.|:.|.:.|....|.
Human   265 TRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYR 329

  Fly   181 LSVLGKYSGDAGDSLRYHKGMP-----FSTFDHDDTGH---GCARIYVGAWWYDQCQRSNLNGQY 237
            |.| |.|:|.|||:||::|...     |:|.|.|:..:   .|...|...||:|.|..:||||:|
Human   330 LHV-GNYNGTAGDALRFNKHYNHDLKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLSANLNGKY 393

  Fly   238 LEGGRFEPKMSG--RGITWMSW--------RGYDYGYKFVQMMIRPK 274
                 :..|..|  .||.|.:|        .||...:|..:||||||
Human   394 -----YHQKYRGVRNGIFWGTWPGVSEAHPGGYKSSFKEAKMMIRPK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30281	NP_726164.1	FReD	63..274	CDD:238040	89/231 (39%)
FGL2	NP_006673.1	DUF460	<28..>161	CDD:331991	9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..126
		FReD	209..435	CDD:294064	89/231 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810