DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30275 and CG30268

DIOPT Version :9

Sequence 1:	NP_788430.3	Gene:	CG30275 / 246522	FlyBaseID:	FBgn0050275	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	NP_611712.2	Gene:	CG30268 / 37610	FlyBaseID:	FBgn0050268	Length:	1240	Species:	Drosophila melanogaster

Alignment Length:	1315	Identity:	431/1315 - (32%)
Similarity:	702/1315 - (53%)	Gaps:	146/1315 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NKLIRSPGVKWFGNIRPKFRGK-------------DSLFNSYQTYRILAF-CTESSALVAYAEFR 68
            |.||.:.|::....|...:..|             |:||...|..|::.: ..|...|:||:||.
  Fly     7 NILIVTAGIRDQRRIEDLYDAKSTWHFGVKETPPLDTLFLKNQAQRLIVYNKQEYHLLLAYSEFA 71

  Fly    69 NYPSIAALPTDCWLEWLSTRYCLSMSISWLNALFFNFCVYKSDQSPVLVEIIKDVLYRESRVWFL 133
            |:|:|..|..|.||.||:.|:|:.:.|:.|||:||||.:.|...|.:|.::|.:|.|.|..|.::
  Fly    72 NHPNIPVLANDLWLHWLNVRFCVDLPITLLNAIFFNFFICKDGHSQMLKKVILEVFYTEHLVNYM 136

  Fly   134 ITVRCPYVPQPIHFVETFDDLEKISQVFYPLEYSMDKNNNTQSLYIVDRFVILPRITYRKALAED 198
            :..:.|..|.     ..:|.::.....:||....:.:..:..::.::.|...:|.:::||||.||
  Fly   137 LVFKPPDCPP-----GQYDAVQAFGTTYYPKHSKVSEQKHLPAVIVIQRRSTMPVLSFRKALPED 196

  Fly   199 NDDIIAMQEVENPEMREELGDYYIAEEVMG-------QNPKSMLVVAETINQSQESEMAI----- 251
            ||||:.|.:.|:||:|::.||:||||.::.       .|.|  :::||.     |.|:|.
  Fly   197 NDDIVEMIDSEDPELRKKHGDFYIAEHLLNAEGSDSDHNDK--IIIAEF-----EEEIADNVKGA 254

  Fly   252 -FLWLSSDIDIMFYVRNYEMEQFGNLVKPADGRSFHYETMTVSSVQRRAEASMFTADALDDLNAV 315
             .:|||..:||.....||.:|:.||||:...|.:..:....|.||:.::...:||...:::..
  Fly   255 GLMWLSQSLDIKMLATNYHLERLGNLVRYTPGCTHAHVGFEVISVELKSYKELFTRKQMEERY-- 317

  Fly   316 TILGGLQKVDSGMSVASLGKMKVSSIGGTIVDTNVANENKFYMRECLYSKFKYILEKLHSTDYYL 380
                               |..||.|     :|:..:|.    |..|:.|:|:|.|:|....||:
  Fly   318 -------------------KSHVSRI-----NTDGQDET----RNILFKKYKHIYEELREGVYYI 354

  Fly   381 -RHEQSV-INFIYPAGTEPAGP---AAMAAASNVFLLRCIVARQDFPLPR---LFNAMVAIFSAY 437
             .|:..: |:|..|.|.:....   ..:|.|||.|||:..   |..||.|   .|.::.|:|||:
  Fly   355 TAHQDKLEISFDLPDGEKSTSENRLQYLAKASNGFLLKMF---QLHPLVRYEYTFYSLSAMFSAF 416

  Fly   438 PDRDYCMMLMSVKYKASKSYLEVMQYFMPVASRPSNLSSLDDVFITHRSTIFGEISLYKLEKEDV 502
            ||.|||:.|:......|....|::::|:|||.|||:..| :::|:.||||:|||:.:::.|.:::
  Fly   417 PDHDYCVTLVPANVSTSPCQRELLRFFLPVAHRPSSTVS-ENLFVAHRSTLFGELRVHRFESQEI 480

  Fly   503 AHVHKLALGNLPSNTQTPNSSSSSFSYCSK--VNEREELEHELHVLDAIMKDVLENEFSEFAVFT 565
            ..:..|    :....:...|.|...|..||  .|..|::   |.:.:.|::::||:...:...||
  Fly   481 DEIRTL----ISKQARKRESLSEDDSEDSKGIDNYTEDV---LSIFEDIIREILEDPMCDLTCFT 538

  Fly   566 IRCGISTRSVRENTAIGFVIVREFHSHEKLFEHYHLPKQEYQLNRRRAEIISLRLHPLFLVSAGL 630
            ||||.|.:.. :...:||:|:|.|..::.:.:.:.:|:.::.|..:|.||:..||||.|.:....
  Fly   539 IRCGQSKKHT-DCPLVGFIILRPFLVYDDISKIFMMPRDQFSLTHKRGEIVMFRLHPFFQMWCKT 602

  Fly   631 IFRDLARKTSFYDYYFIHSVDGYKYSNDLKKMMMVVEPKPIKK-VPVFTRVQANHKKPRKKLDLP 694
            |.|.:|...::.:.|:||...|....|||...||.:||:.:|| :..:..|....:..:.|:.:
  Fly   603 ILRTVALCDNYRELYYIHFFSGISLPNDLMYNMMPIEPRRMKKNLFNYKCVSLRRRVAKGKMSV- 666

  Fly   695 PPNFSRD----NLIIYRHKLNPVKWFTNSQKLVIIGFSAVTKAFLRQLVFQWNSKDHKNSENFTC 755
              |.|.|    .:.::.|.|.|.........|:|:|||:...||||.::|.|||||..|.:.:.|
  Fly   667 --NVSMDICTSRMRLFCHNLQPTMHMGGKNSLLIVGFSSTCMAFLRTVIFAWNSKDLINYKKYNC 729

  Fly   756 LTRLQVTVICRAGIVEADYDSLFKCPYCTNRQGCYLSYRNESCYVRDCCMRIDLRCWVHFVPGKV 820
            |..:.:||:...||:|:.||..|.|.:|.|.:.||:...|.:.:|||...|:|:|.||.||.|:|
  Fly   730 LPMVDITVLVGHGIIESAYDCDFSCNFCANARNCYVDTGNVNPFVRDTMQRMDVRHWVRFVSGEV 794

  Fly   821 EKVDRDKKFVKL-DSCEIYYDTLLLMC-------DRMFVLRCIDVPVYSPRPCNLVEINFRLNKF 877
            :.:.|.:|.|:| |.|.:|||.|:||.       |:.|        ...|.|.|.|..|.||::.
  Fly   795 KSIKRQEKVVELSDGCHLYYDKLVLMGATRYGFEDKEF--------KGHPIPLNYVVNNTRLDRI 851

  Fly   878 LLFYKVRALLEDMPRTYLVLVYGNNLHTYECIAFLIGHGVDCSRMVFVQPH-RITGRDADMKEKC 941
            :.::||..::|.| .:|.::|||.||..||||.||:.||.....:::|||| .|...|..:.||
  Fly   852 IFYHKVCEMVELM-ESYYIIVYGYNLCIYECIHFLVTHGCKAQNIIYVQPHVPIVMEDLGIPEK- 914

  Fly   942 PYWDKNLQMIMDDILVEKGVNIFTDYDFHHYNLHKSTDFIMEVIFQHFPTQKQMTFECDLFISFQ 1006
               |..|..|:.:::.:.||.|:...::..:.|.:....|.:|.....|::|::...||||:::.
  Fly   915 ---DSRLDPIILEMIADLGVTIYLSTNYSQFILSQDNMNIEKVELIMHPSKKKIVLHCDLFVNYN 976

  Fly  1007 EGHLHQRHKQWLENAGIELDGNQILVNERYQTNDPDVYAAGSFIKMRITPNYQYKFVSERELARK 1071
            :..:....:..|..||||:...:|:||.||.|||.:::|||..:.|...||:||.:.|.:|:|.|
  Fly   977 DNTISSSMENVLSEAGIEISERRIVVNSRYCTNDRNIFAAGINVIMIPKPNFQYTYGSPQEMAEK 1041

  Fly  1072 ILHHLGIVTDKNFEDRFAEPVLFQAILPLRYFITKVTMPRRYLLSQVPVIKNCNLTTYKNKTFCR 1136
            :.:.|.:: ....:.|:::|.:|..|||:.|.|.|:|.|:..|:.|:|:..:..||||.:..|||
  Fly  1042 LAYELNMI-KVVMQSRYSKPYMFTGILPMGYQIIKITQPKPLLIGQLPIEFSETLTTYDDGDFCR 1105

  Fly  1137 VGLSTRMMVDEIVVVTKKECNLDFLLYFCGKHELLLNKLKSRYRANLIHCFLKFFQEPWTELIMH 1201
            :.|:.:::|.|||.||||...|.|:.||||||.:|||.|:.|::|..|..||.|||:|||||:||
  Fly  1106 IRLNNKLIVIEIVCVTKKPKRLYFMEYFCGKHAMLLNDLRGRFQAGWIQNFLDFFQQPWTELLMH 1170

  Fly  1202 DDFEELQAENKELLSPMAISALSRPGRGALGELTDMDFFTLNKR---------YIELKLLTFLRE 1257
            |.||:||.:|:.||..|.:             :.:.|  |.|.|         .:|..::.|:|.
  Fly  1171 DRFEDLQLKNRRLLLSMLL-------------MNNKD--TNNPRNSLENTQRLRLEENVIDFVRT 1220

  Fly  1258 HRRDFRHKFALPEDF 1272
            :|:||.|:||||||:
  Fly  1221 YRKDFTHEFALPEDW 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30275	NP_788430.3	DUF4821	5..279	CDD:292710	91/287 (32%)
CG30268	NP_611712.2	DUF4821	14..286	CDD:292710	88/283 (31%)
CG30268	NP_611712.2	Pyr_redox_2	<793..1017	CDD:285266	77/236 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471424
Domainoid	1	1.000	116	1.000	Domainoid score	I5960
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57462
OrthoDB	1	1.010	-	-		D120508at33208
OrthoFinder	1	1.000	-	-		FOG0009665
OrthoInspector	1	1.000	-	-		otm26313
orthoMCL	1	0.900	-	-		OOG6_104363
Panther	1	1.100	-	-	P	PTHR21178
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	9.000