DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30275 and Cfap61

DIOPT Version :9

Sequence 1:	NP_788430.3	Gene:	CG30275 / 246522	FlyBaseID:	FBgn0050275	Length:	1298	Species:	Drosophila melanogaster
Sequence 2:	XP_008760507.2	Gene:	Cfap61 / 311496	RGDID:	1311519	Length:	1235	Species:	Rattus norvegicus

Alignment Length:	1369	Identity:	283/1369 - (20%)
Similarity:	532/1369 - (38%)	Gaps:	253/1369 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RLAQAGDQDGLNKLIRSPGVKWFGNIRPKFRGKDSLFNSYQTYRILAFCTESSALVAYAEFRNYP 71
            |..::.|...:..|||....|.||.:       :.::...:....:..|.:...::|::.|.:||
  Rat    17 RRTESQDIFCIKTLIRKFTQKLFGRL-------NIIYLLEKANLAVTVCNDKEEIMAHSIFVDYP 74

  Fly    72 SIAALPTDCWLEWLSTRYCLSMSISWLNALFFNFCVYKSDQSP-VLVEIIKDVLYRESRVWFLIT 135
            :......|.|:. :.......:..:.||.||.:|.|...:.:. .|.|||:.|......::|:..
  Rat    75 NWNVAKQDNWIP-VFRELDKEIPCTPLNTLFMHFFVAVDEYATGCLKEIIRTVFKAVPELYFIFL 138

  Fly   136 VRCPYVPQPIHFVETFDDLEKISQVFYPLEYSMDKNNNTQSLYIVDRFVILPRITYRKALAEDND 200
            :...|:......:..||.:..|..:.|..|:         :::|..|....|::..|||..||:|
  Rat   139 IVPTYLSLGSTLITVFDQVGNIPCMNYDEEF---------AVHICHRHDHYPQLHIRKARVEDHD 194

  Fly   201 DIIAMQEVENPEMREELGDYYIAEEVMGQNPKSMLVVAETINQSQESEMAIFLWLSSDIDIMFYV 265
            |::.:....:..::|..|:|::||.:..|:..:..||.|.     |.:...|:.:.:.:::....
  Rat   195 DLMPIFMHYDSTLKEIYGEYFLAELIEAQDEDNHAVVCEV-----EGKAVGFMSVCASVNLPLLH 254

  Fly   266 RNYEMEQF--------GNLVKPADGRSFHYETMT-----VSSVQRRAE--ASMFTADALDDLNAV 315
            ..:::..|        .:|::|....|......|     ....||..|  .|:.|::.:.:.:..
  Rat   255 ECFDLGPFHGFCFPHPDDLLEPPKEPSLEESEDTGNKSDSQGSQRVVEEPVSIDTSEMIQEKDTE 319

  Fly   316 T------ILGGLQKV-------DSGMSVASLGKMKVSSIGGTIVDTNVANENKFYMRECLYSKFK 367
            |      :|..|.||       :..:|:.||                 .:|:.|.....|.|...
  Rat   320 TSISCEEVLSLLSKVSEDMQDLEKNLSIISL-----------------VDEDDFGSLSSLSSSLL 367

  Fly   368 YILEKLHSTDYYLRHEQSVINFIYPAGTEPAGPAAMAAASNVFLLRCIVARQDFPLPRLFNAMVA 432
            ..:|..|....||..                      :|:....|.||..|.:   .|..:.|..
  Rat   368 LSVESSHFRPLYLGE----------------------SAAFCIQLFCIDERYE---ARSLDFMSF 407

  Fly   433 IFSAYPDRDYCMMLMSVKYKASKSYLEVMQYFMPVASRPSNLSSLD-DVFITHRSTIFGEISLYK 496
            :||.:|::::|  |:||.:...:..|  :|.|:.|.  |.:..:|| |:::.||:.:...|::..
  Rat   408 VFSLFPNKNFC--LISVPHLTPEFVL--IQNFVKVV--PFSNCTLDNDLYVFHRAGLLRSITIRL 466

  Fly   497 LEKEDVAHVHKLALGNLPSNTQTPNSSSSSFSYCSKVNEREELEHELHVLDAIMKDVLENEFSEF 561
            .:..|...|.||        .:|...|:...|..::.||...                :.:.:|.
  Rat   467 AKFLDTPGVEKL--------VRTLLLSTKILSDLAQYNEAGR----------------DPDGTEL 507

  Fly   562 AVFTIRCGISTRSVRENTAIGFVIVREFHSHEKLFEHYHLPKQEYQLNRRRAE---IISLRLHPL 623
            .||.....        |..:|..::|:....|.:..||::....|..:.::.|   :....|:|:
  Rat   508 QVFVAEVA--------NQIVGIAVIRKEMDIEYIRSHYNIEDFIYFSHHQQEEHGRLNHFALNPI 564

  Fly   624 FLVSAGLIFRDLAR---KTSFYDYYFIHSVDG---YKYSNDLKKMMMVVEPKPIKKVPVFTRVQA 682
            |........:::.|   |:..|...:..:.:|   ..|::.|...:..:       |||..|.|.
  Rat   565 FRHYTKFFLKEILRLGYKSCLYYPVYSQTREGKLQSSYAHSLTSALHYL-------VPVRPRRQI 622

  Fly   683 NHKKPRKKLDLPPPNFSRDN----LIIYRHKLNPVKWFTNSQKLVIIGFSAVTKAFLRQLVFQWN 743
            .:...:..::.|....|:|.    |.....||......|.:.::|::|.|:|..:||..|||
  Rat   623 VYPLEKLGINAPSKEVSKDQASYALNHTNRKLTLEPKVTVNARIVVVGASSVGISFLETLVF--- 684

  Fly   744 SKDHKNSENFTCLTRLQVTVICRAGIVEADYDSLFKCP---YCTNRQGCYLSYRNESCYVRDCCM 805
             ..|....|        :|:|...|:           |   ..:|.|..:|:  ::.|:.....:
  Rat   685 -CSHLKFNN--------LTLISTHGL-----------PGKKLLSNEQRKFLA--SDHCFNDKDYV 727

  Fly   806 RIDLRCWVHFVPGKVEKVDRDKKFVKLDSCEI-YYDTLLLMCDRMFVLRC------------IDV 857
            .:.|..||:.|.|::..:||..|.|.:...|| :||.|:|...:.:.:.|            .:|
  Rat   728 LMSLCSWVNVVVGRMTAIDRVAKQVVVSKDEIVFYDHLILCTGQQYQVPCPTGADIEQHLTNREV 792

  Fly   858 PVYSPR------PCNLVEINFRLNKFLLFYKVRALLEDMPRTYL----VLVYGNNLHTYECIAFL 912
            ...|.|      |.||..:|...:      .||||......:.|    |:||||.|..|..:..|
  Rat   793 MQLSKRRYTGTVPSNLFILNDEED------CVRALFWLRNNSTLTEGKVIVYGNTLDAYTTVETL 851

  Fly   913 IGHGVDCSRMVFVQPHRITGRDADMKEKCPYWDK-NLQMIMDDILVEKGVNIFTDYDFHHYNLHK 976
            :..|::.:.:.||.|        ..:....|.:. :::..:|:.|...||.::.|.....:|..:
  Rat   852 LHIGMEGNCIYFVHP--------PAESNTTYINNYDIESAVDEALSAAGVKVYQDALLAQWNQGQ 908

  Fly   977 STDFIMEVIFQHFPTQKQMTFECDLFISFQEGHLHQRHKQWLENAGIELDGNQILVNERYQTNDP 1041
            ..|.|....|.  .:.|....||..|.||.:.::.....:...:|.:..|| :::::..:.|||.
  Rat   909 DPDPIQNACFT--TSTKPFRLECSAFFSFYKKNVDYETFKAFNDACLVYDG-RLVIDTTFHTNDI 970

  Fly  1042 DVYAAGSFIKM--RITPN-YQYKFVSERELARKILHHLGIVTDKNFEDRFAEPVLFQAILPLRYF 1103
            .:.|||...|.  |...| :.:...|.:|:..::...:..:.|...|.....|.....::|: |.
  Rat   971 AIRAAGPLTKFSNRYYSNEWTHSNFSSKEIGFQLAAAMLSLFDPTLEPVTEPPADLDRLIPM-YK 1034

  Fly  1104 ITKV---TMP--RRYLLSQVPVIK------------NCNLTT--YKNKTFCRVGLSTRMMVDEIV 1149
            ..|:   .:|  ..||....|.|.            ...:.|  .|..|:.|:..:...:|:.|.
  Rat  1035 GAKIQGGILPGSYHYLHISKPAIPTPLDVQRSQPDFGSEIVTGNAKKGTYFRLYFNNYKLVEAIT 1099

  Fly  1150 VVTKKECNLDFLLYFCGKHELLLNKLKSRYRANLIHCFLKFFQEPWTELIMHDDFEELQAENKEL 1214
            ..:|:.......:...|:||.:||.|.:|:...||.....:|.|||...:.||.|.:|:.|.:::
  Rat  1100 CFSKEPFPTSNYIRLFGQHEQVLNNLCTRFDEKLIPDLYSYFTEPWCMALFHDRFIDLKKELRQI 1164

  Fly  1215 LSPMAISALSRPGRGALGELTDMDFFTLNKRYIELKLLTFLREHRRDFRHKFALPEDFLKLDLAD 1279
            ::  :.....:|....:....:.:...||:     |...:|::...|..:|..|.:..  ||...
  Rat  1165 IT--SKQEEDQPTMEQIARQLEEEEINLNE-----KPQKYLQKVFEDSIYKSLLEKSI--LDYLH 1220

  Fly  1280 YERY 1283
            |.:|
  Rat  1221 YNQY 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30275	NP_788430.3	DUF4821	5..279	CDD:292710	56/280 (20%)
Cfap61	XP_008760507.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120508at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010