Protein Alignment CG30275 and CFAP61

DIOPT Version :9

• Sequence 1: NP_788430.3
• Gene: CG30275 / 246522
• FlyBaseID: FBgn0050275
• Length: 1298
• Species: Drosophila melanogaster
• Sequence 2: XP_005260745.1
• Gene: CFAP61 / 26074
• HGNCID: 15872
• Length: 1242
• Species: Homo sapiens
• Alignment Length: 1296
• Identity: 282/1296 - (21%)
• Similarity: 519/1296 - (40%)
• Gaps: 225/1296 - (17%)

  Fly     7 RLAQAGDQDGLNKLIRSPGVKWFGNIRPKFRGKDSLFNSYQTYRILAFCTESSALVAYAEFRNYP 71
            |..::.|...:..|||....|.||.:       :.::...:....:..|.:...::|.|.|.:||
Human    17 RRTESQDVYCIKSLIRKFTCKLFGKL-------NIIYLLEKANLAVTLCNDKEEIMAQATFLDYP 74

  Fly    72 SIAALPTDCWLEWLSTRYCLSMSI--SWLNALFFNFCVYKSDQS-PVLVEIIKDVLYRESRVWFL 133
            :......|   :|:|....|...|  :.||.||.:..|...:.| ....||::.|......:.|:
Human    75 NWNVAKQD---DWVSVFRELDSDIPCTPLNTLFMHLFVAVDEYSVGCCKEILRTVYKAVPELHFI 136

  Fly   134 ITVRCPYVPQPIHFVETFDDLEKISQVFYPLEYSMDKNNNTQSLYIVDRFVILPRITYRKALAED 198
            ..:...|:......:..||.:..|..:.|..::         :::|..|....|::..|||..||
Human   137 FLIVPSYMSLGSTLITVFDQVGNIPCLTYEEDF---------AVHICHRHSHYPQLHVRKARVED 192

  Fly   199 NDDIIAMQEVENPEMREELGDYYIAEEVMGQNPKSMLVVAETINQSQESEMAIFLWLSSDIDIMF 263
            :||::.:....:..::|..|:|::||.:..|:.::..||.|.     |.....|:.:.|.:::..
Human   193 HDDLMPIFMRYDTILKETYGEYFLAELIEAQDEENHAVVCEV-----EGTAVGFMSVCSRVNMQL 252

  Fly   264 YVRNYEMEQFGNLVKPADGRSFHYETMTVS----SVQRRAEASMFTADALDDLNAVTILGGLQKV 324
            ....:::..|..|..|      |.:.:..|    ||:|..:|.:.::..           |.||:
Human   253 LHECFDLGPFHGLCFP------HPDDVLESPQDLSVRRSQDAELRSSSQ-----------GSQKI 300

  Fly   325 DSGMSVASLGKMKVSSIGGTIVDTNVANENKFYMRECLYSKFKYILEKLH--STDYYLRH---EQ 384
            ...:. ..:....:.:|.|.|.....:.|....::....|:.:.| |||.  ||.|...|   .:
Human   301 VEELQ-EPVSPDTMENIQGNIAREAASEEALTAVQSGNVSEPEDI-EKLSDISTGYAQYHHVSSR 363

  Fly   385 SVINFIYPAGTEPAGPAAM---AAASNVFLLRCIVARQDFPLPRLFNAMVAIFSAYPDRDYCMML 446
            |:.:.:.|  .||.....:   |:|:....|.||..:.:   .|..:.|..:||.:.|:::|  :
Human   364 SLASLVLP--EEPVHFRPIYRGASAAFCIQLFCIDEKYE---ARSLDFMNFVFSLFSDKNFC--V 421

  Fly   447 MSVKYKASKSYLEVMQYFMPVASRPSNLSSLD-DVFITHRSTIFGEISLYKLEKEDVAHVHKLAL 510
            :|:.:...:.:|  :|.|:.:.  |.|..:|: |:::.||:.:...|::......|...|.
Human   422 ISLPHLTPEFFL--IQNFVKMV--PFNTCTLEQDLYVFHRAGLLKSINIRFATLLDTPGVE---- 478

  Fly   511 GNLPSNTQTPNSSSSSFSYCSKVNEREELEHELHVLDAIMKDVLENEFSEFAVFTIRCGISTRSV 575
             ||.|......|........:|.  |::.:..|  |.|.:.:|.|.
Human   479 -NLVSTLMLNKSILEDLDRYNKA--RKDPDGTL--LQAFVAEVAEQ------------------- 519

  Fly   576 RENTAIGFVIVREFHSHEKLFEHYHLPKQEYQLNRRRAE---IISLRLHPLFLVSAGLIFRDLAR 637
                .:|..::|.....|.:..||::....|..:.:|.|   :....|:|:|........:::.|
Human   520 ----IVGIAVIRNEMDIEYIRSHYNIEDFIYFSHHQREEHGHMHHFALNPIFRHYTKFFLKEILR 580

  Fly   638 ---KTSFYDYYFIHSVDG--------YKYSNDLKKMMMVVEPKPIKKVPVFTRVQANHKKPRKKL 691
               |:..|...:..|.:|        ..|::.|...:..:.|...::..|:...:.....|.|.:
Human   581 LGFKSCLYYRVYPKSREGKIAVFQFQNPYAHSLTSALHYLVPVRPRRQIVYPLEKLGINAPSKAV 645

  Fly   692 DLPPPNFSRDNLIIYRHKLNPVKWFTNSQKLVIIGFSAVTKAFLRQLVFQWNSKDHKNSENFTCL 756
            ...|.:::.::.   ..||......|.:.|::::|.|:|..:||..|||..:.|       |..|
Human   646 SKDPMSYALNHT---NRKLTLEPKITVNAKIIVVGASSVGISFLETLVFCSHMK-------FNNL 700

  Fly   757 TRLQVTVICRAGIVEADYDSLFKCPYCTNRQGCYLSYRNESCYVRDCCMRIDLRCWVHFVPGKVE 821
            |.:....:....:::.:........:|.|.:...|               :.|..||:.|.|::.
Human   701 TLISTHGLPGKKLLDTEQRKFLASDHCFNDKDYAL---------------MSLCSWVNVVVGRMT 750

  Fly   822 KVDRDKKFVKLDSCEIY-YDTLLLMCDRMFVLRC------------IDVPVYSPR------PCNL 867
            .:||..|.|.|.:.||. ||.|:|...:.:.:.|            .:||..|.|      |||
Human   751 GIDRAAKHVVLSTDEIVPYDHLILCTGQQYQVPCPTEADISQHLTNREVPNSSQRRYTGKVPCN- 814

  Fly   868 VEINFRLN------KFLLFYKVRALLEDMPRTYLVLVYGNNLHTYECIAFLIGHGVDCSRMVFVQ 926
               :|.||      |.|::.:..::..:..    ::||||.:.||..:..|:..||..||:..||
Human   815 ---HFTLNEEEDCFKALIWIRNNSITTEGN----IIVYGNTIDTYTTVETLLNLGVSGSRIHLVQ 872

  Fly   927 P---HRITGRDADMKEKCPYWDKNLQMIMDDILVEKGVNIFTDYDFHHYNLHKSTDFIMEVIFQH 988
            |   ..||..:          :.:::..:.|.|...||.::.|.....:|.....|.|....|.
Human   873 PPPASTITCIN----------NYSVESAVADALGAAGVTMYRDAILAQWNDGLHPDPIYSASFT- 926

  Fly   989 FPTQKQMTFECDLFISFQEGHLHQRHKQWLENAGIELDGNQILVNERYQTNDPDVYAAGSFIKMR 1053
            .|| |....:|.:|.||.|.::.....:.|.:|.:..| ::::::..:.|||..:.||||..|.
Human   927 TPT-KPFRLQCSMFFSFCEKNVDYETFKALNDACLVYD-SRLVIDTNFHTNDIAIRAAGSLTKF- 988

  Fly  1054 ITPNYQY-------KFVSER---ELARKILHHLGIVTDKNFEDRFAEPVLFQAILPL-------- 1100
              .|..|       .|.|:.   :||..:||    :.|...|.....|.....::|:
Human   989 --SNRYYSNEWTHSNFSSKEIGFQLAAAMLH----LFDPTLEPVTEPPANLDRLIPMYKGAKIQG 1047

  Fly  1101 -------RYF-ITKVTMPRRYLLSQVPVIKNCNLTT--YKNKTFCRVGLSTRMMVDEIVVVTKKE 1155
                   .|. |.|..:|....:..........|.|  .||.|:.|:.::...||:.|..::::.
Human  1048 GILPGSYHYLHIAKPAIPTPLEVQMAQPNYGLELVTGSAKNGTYFRIHINKYKMVETITCLSREP 1112

  Fly  1156 CNLDFLLYFCGKHELLLNKLKSRYRANLIHCFLKFFQEPWTELIMHDDFEELQAENKELLS 1216
            ......:...|:||.|||.|.:||..|||.....:|.|||...:.||.|.:|:.|.:::|:
Human  1113 FPASNYIRLFGQHEQLLNNLCARYDENLITDLYSYFTEPWCLALFHDRFIDLRKELRQILA 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30275	NP_788430.3	DUF4821	5..279	CDD:292710	58/274 (21%)
CFAP61	XP_005260745.1	DUF4821	15..268	CDD:318340	58/274 (21%)
		NirB	672..>777	CDD:330997	32/126 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159856
Domainoid	1	1.000	116	1.000	Domainoid score	I5960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57462
OrthoDB	1	1.010	-	-		D120508at33208
OrthoFinder	1	1.000	-	-		FOG0009665
OrthoInspector	1	1.000	-	-		otm40963
orthoMCL	1	0.900	-	-		OOG6_104363
Panther	1	1.100	-	-	LDO	PTHR21178
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910